Contact HealthDay
Tel: 203.855.1400 or E-mail

News By Specialty

Allergy
Anesthesiology
Cardiology
Cosmetic Surgery
Critical Care
Dermatology
Diabetes & Endocrinology
Emergency Medicine
Family Practice
Gastroenterology
Geriatrics
Hematology & Oncology
HIV & AIDS
Infectious Disease
Internal Medicine
Nephrology
Neurology
Nursing
OBGYN & Women's Health
Ophthalmology
Orthopedics
Otolaryngology
Pain Management
Pathology
Pediatrics
Pharmacy
Psychiatry
Pulmonology
Radiology
Rheumatology
Surgery
Urology

Follow us on:

    


e-Healthcare Leadership Awards


Gastric Surgery in Diabetes Changes Stimulus Response
Surgery improves glucose tolerance but worsens endogenous glucose production

WEDNESDAY, July 17 (HealthDay News) -- In obese patients with type 2 diabetes, gastric bypass surgery changes the postprandial response, improving glucose tolerance, β-cell function, and insulin sensitivity while worsening endogenous glucose production in response to a stimulus, according to a study published online July 8 in Diabetes.

Stefania Camastra, M.D., from the University of Pisa in Italy, and colleagues administered a mixed meal to 10 obese patients with type 2 diabetes and 11 obese patients without diabetes before and one year after gastric bypass surgery to examine glucose tolerance and insulin sensitivity.

The researchers found that after surgery, both groups had a biphasic oral glucose appearance, postprandial glucose levels, and insulin secretion. In patients with type 2 diabetes, fasting and postprandial glucose levels were lower and peripheral insulin sensitivity increased in proportion to weight loss after surgery. Although β-cell glucose sensitivity doubled, sensitivity did not normalize compared with nonsurgical obese and lean controls. During the mixed meal, endogenous glucose production was less suppressed due to a relative hyperglucagonemia and a rapid fall in plasma glucose and insulin levels.

"We conclude that in type 2 diabetes, bypass surgery changes the postprandial response to a dumping-like pattern, improves glucose tolerance, β-cell function, and peripheral insulin sensitivity but worsens endogenous glucose output in response to a physiological stimulus," Camastra and colleagues write.

Abstract
Full Text (subscription or payment may be required)



Copyright © 2013 HealthDay. All rights reserved.

April 23, 2014

Archive Search

By Keyword:
By Category:
By Topic:

Related Articles

Obstructive Sleep Apnea Linked to Osteoporosis CME

Lipid Genes Have Pleiotropic Impact on Glucose-Linked Traits CME

FDA Approves Cyramza for Gastric Cancer

Type of Attending Doc Affects Feeding Tube Rates in Elderly

Acetazolamide and Low-Sodium Diet Improve Vision

Conservative Management Better for Arteriovenous Malformations