Contact HealthDay
Tel: 203.855.1400 or E-mail

News By Specialty

Allergy
Anesthesiology
Cardiology
Cosmetic Surgery
Critical Care
Dermatology
Diabetes & Endocrinology
Emergency Medicine
Family Practice
Gastroenterology
Geriatrics
Hematology & Oncology
HIV & AIDS
Infectious Disease
Internal Medicine
Nephrology
Neurology
Nursing
OBGYN & Women's Health
Ophthalmology
Orthopedics
Otolaryngology
Pain Management
Pathology
Pediatrics
Pharmacy
Psychiatry
Pulmonology
Radiology
Rheumatology
Surgery
Urology

Follow us on:

    


e-Healthcare Leadership Awards


No MI Rate Advantage for Aggressive T2DM Glucose Control
More aggressive strategies do not reduce rate of myocardial infarction or preserve renal function

THURSDAY, Aug. 1 (HealthDay News) -- In patients with type 2 diabetes, more aggressive glucose-control strategies have variable short-term effects on microvascular complications, but they do not reduce the rate of myocardial infarction over four years of follow-up, according to a study published online July 22 in Diabetes Care.

Romain Neugebauer, Ph.D., of Kaiser Permanente in Oakland, Calif., and colleagues conducted a cohort study involving 58,000 adults with type 2 diabetes who had A1C <7 percent while taking two or more oral agents or basal insulin; subsequent A1C levels increased from ≥7 percent to 8.5 percent. The effect of progressively more intensified glucose-control strategies initiated at A1C of ≥7, ≥7.5, ≥8, or ≥8.5 percent with subsequent control for treatment adherence was assessed.

The researchers found that, after multivariable adjustment, including for age, sex, race/ethnicity, comorbidities, blood pressure, lipids, and body mass index, increasingly more aggressive strategies for glucose control were associated with reduced onset or worsening of albuminuria. However, progressively aggressive glucose-control strategies were not linked with changes in major clinical outcomes during four years of follow-up, such as reductions in the occurrence of myocardial infarction or preservation of renal function.

"In a large representative cohort of adults with type 2 diabetes, more aggressive glucose-control strategies have mixed short-term effects on microvascular complications and do not reduce the myocardial infarction rate over four years of follow-up," the authors write. "These findings are consistent with the results of recent clinical trials, but confirmation over longer periods of observation is needed."

Abstract
Full Text (subscription or payment may be required)



Copyright © 2013 HealthDay. All rights reserved.

July 23, 2014

Archive Search

By Keyword:
By Category:
By Topic:

Related Articles

Decreased Vision Tied to Unemployment

Online Reviews Show Patients Value Docs' Interpersonal Skills

Utility of CIMT Varies With Thoroughness of Assessment

Use of Catheter-Directed Thrombolysis Increasing

Albumin, Creatinine Blood Tests Might Help Predict ALS Survival

New Strategy IDs Patients With Undiagnosed Hypertension CME