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e-Healthcare Leadership Awards


CONTINUING MEDICAL EDUCATION INFORMATION

Release Date: November 11, 2013
Last Reviewed: November 7, 2013
Expiration Date: November 11, 2014
Time to Complete Activity: 15 minutes

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This activity has been designed to meet the educational needs of physicians with an interest in Diabetes & Endocrinology, as well as other health care professionals.

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  • Summarize the significance of the study in the context of clinical care.

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In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

Neither Paradigm Medical Communications, LLC, staff nor HealthDay's medical writer have financial relationships to disclose.

Peer reviewer, Cynthia Haines, M.D., has the following financial relationships to disclose:

  • Salary/Ownership Interest (stocks, stock options, or other ownership interest) - GlaxoSmithKline (Spouse)
ASN: ACE Inhibitor Plus ARB No Benefit in Diabetic Nephropathy
Increased risk of hyperkalemia and acute kidney injury; safety concerns resulted in early end to trial

MONDAY, Nov. 11 (HealthDay News) -- For patients with diabetic nephropathy, combination treatment with an angiotensin-converting enzyme (ACE) inhibitor and angiotensin-receptor blocker (ARB) has little clinical benefit and is associated with an increased risk of adverse events, according to a study published online Nov. 9 in the New England Journal of Medicine. This research was published to coincide with the annual meeting of the American Society of Nephrology (Kidney Week), held from Nov. 5 to 10 in Atlanta.

Linda F. Fried, M.D., M.P.H., from the Veterans Affairs Pittsburgh Healthcare System and University of Pittsburgh, and colleagues examined the safety and efficacy of losartan in combination with lisinopril for patients with type 2 diabetes, a urinary albumin-to-creatinine ratio of at least 300, and an estimated glomerular filtration rate (GFR) of 30.0 to 89.9 ml per minute per 1.73 m² of body surface area. A total of 1,448 patients received losartan and were then randomized to receive lisinopril or placebo.

Due to safety concerns, the study was stopped early. The researchers found that over a median follow-up of 2.2 years there were 152 primary end point events (first occurrence of change in the estimated GFR, end-stage renal disease, or death) in the monotherapy group and 132 in the combination-therapy group (P = 0.30). No benefit was seen in mortality or cardiovascular events. Compared with monotherapy, combination therapy correlated with increased risk of hyperkalemia and acute kidney injury.

"Use of combination therapy with an ACE inhibitor and an ARB in patients with proteinuric diabetic kidney disease does not provide an overall clinical benefit," the authors write.

The Investigator-Initiated Studies Program of Merck provided the study drugs. Several authors disclosed financial ties to pharmaceutical companies, including Merck.

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September 2, 2014

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