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e-Healthcare Leadership Awards


CONTINUING MEDICAL EDUCATION INFORMATION

Release Date: May 13, 2014
Last Reviewed: May 8, 2014
Expiration Date: May 13, 2015
Time to Complete Activity: 15 minutes

TARGET AUDIENCE

This activity has been designed to meet the educational needs of physicians with an interest in Diabetes & Endocrinology, as well as other health care professionals.

STATEMENT OF NEED

This activity will supply up-to-date news information to practicing clinicians which can be integrated into practice and aims to increase professional competency.

EDUCATIONAL OBJECTIVES

Upon proper completion of this activity, participants should be better able to:

  • Summarize the significance of the study in the context of clinical care.

DISCLOSURES

In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

Neither Paradigm Medical Communications, LLC, staff nor HealthDay’s medical writer have financial relationships to disclose.

Peer reviewer, Cynthia Haines, M.D., has the following financial relationships to disclose:

  • Salary/Ownership Interest (stocks, stock options, or other ownership interest) - GlaxoSmithKline (Spouse)
Decrease in Fat Cell Volume Improves Insulin Sensitivity
After bariatric surgery, fat cell size strongly linked to improved insulin sensitivity

TUESDAY, May 13, 2014 (HealthDay News) -- For obese women, a reduction in fat cell volume after bariatric surgery is strongly associated with improvement in insulin sensitivity, with the peak incidence seen among older women, according to a study published online April 23 in Diabetes Care.

Daniel P. Andersson, from the Karolinska Institutet in Stockholm, and colleagues examined whether changes in fat cell volume and fat mass correlate with improvements in metabolic risk profile in a cohort of 62 obese women who underwent Roux-en-Y gastric bypass (RYGB). Fat cell volume and number were measured in abdominal subcutaneous adipose tissue before and after RYGB.

The researchers observed a 33 percent decrease in body weight with RYGB, which was accompanied by a decrease in the volume, but not number, of adipocytes. After RYGB, there was a decrease in fat mass in the measured regions and improvement in all metabolic parameters (P < 0.0001). A strong correlation was seen for reduced subcutaneous fat cell size and improved insulin sensitivity (P = 0.0057), but this correlation was not seen for regional changes in fat mass, except for weak associations between changes in visceral fat mass, insulin sensitivity, and triglycerides. After weight loss, there was an alteration in the curve-linear relationship between fat cell size and fat mass (P = 0.03).

"An altered relationship between adipocyte size and fat mass may be important for improving insulin sensitivity after weight loss," the authors write. "Fat cell size reduction could constitute a target to improve insulin sensitivity."

The study was partially funded by the Novo Nordisk Foundation and the European Association for the Study of Diabetes/Lilly.

Abstract
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November 27, 2014

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