April 2019 Briefing - Diabetes & Endocrinology

Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for April 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Rare Variants Identified in DENND1A Gene in PCOS

TUESDAY, April 30, 2019 (HealthDay News) -- Rare variants have been identified in the DENND1A gene that are associated with hormonal traits of polycystic ovary syndrome (PCOS), according to research published online April 30 in the Journal of Clinical Endocrinology & Metabolism.

Abstract/Full Text (subscription or payment may be required)

Combo Nicotine Replacement Tx Ups Success in Quitting Smoking

TUESDAY, April 30, 2019 (HealthDay News) -- People who use combination nicotine replacement therapy (NRT) are more likely to successfully quit smoking than people who use a single form of NRT, according to a review published online April 18 in the Cochrane Database of Systematic Reviews.

Abstract/Full Text

Ambiguous Genitalia in Newborns Not Uncommon

MONDAY, April 29, 2019 (HealthDay News) -- Ambiguous genitalia in newborns may be more common than previously thought, according to a study published online April 24 in the Journal of the Endocrine Society.

Abstract/Full Text (subscription or payment may be required)

Intensive Blood Pressure Therapy Aids Patients With T2DM

MONDAY, April 29, 2019 (HealthDay News) -- Patients with type 2 diabetes who receive intensive treatment to keep their blood pressure levels at 130/80 mm Hg or below experience fewer heart attacks, strokes, and other diabetes complications, according to a study published online April 29 in Hypertension.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Transition Support Program May Aid Young Adults With Type 1 Diabetes

MONDAY, April 29, 2019 (HealthDay News) -- Structured support for patients transitioning from pediatric to adult care for type 1 diabetes may improve outcomes, but those benefits are not sustained after completion of the intervention, according to a study published online April 22 in Diabetes Care.

Abstract/Full Text (subscription or payment may be required)

Events for Living Kidney Donors Mainly Occur After Two Years

MONDAY, April 29, 2019 (HealthDay News) -- Overall, about 14.7 percent of living kidney donors have postdonation events, most of which occur more than two years after donation, according to a study published online April 12 in JAMA Network Open.

Abstract/Full Text

Swapping Red Meat for Plant-Based Proteins May Cut CVD Risk

FRIDAY, April 26, 2019 (HealthDay News) -- Substituting red meat with high-quality plant protein sources, but not with fish or low-quality carbohydrates, leads to greater improvements in blood lipids and lipoproteins, according to a review published online April 9 in Circulation.

Abstract/Full Text

Dapagliflozin Improves Glucose Outcomes in Type 1 Diabetes

FRIDAY, April 26, 2019 (HealthDay News) -- In patients with type 1 diabetes, treatment with dapagliflozin for 24 weeks improves time in range, mean glucose, and glycemic variability, according to a study published online April 9 in Diabetes Care.

Abstract/Full Text (subscription or payment may be required)

Gender Differences Seen in Adverse Drug Reactions

FRIDAY, April 26, 2019 (HealthDay News) -- The risk for adverse drug reactions (ADRs) may be higher for women, even when accounting for gender differences in drug use, according to a study published online April 2 in the British Journal of Clinical Pharmacology.

Abstract/Full Text (subscription or payment may be required)

Over Half of Seniors Initiating Dialysis Die Within One Year

WEDNESDAY, April 24, 2019 (HealthDay News) -- More than half of Medicare beneficiaries initiating dialysis die within one year, according to a research letter published online April 22 in JAMA Internal Medicine.

Abstract/Full Text (subscription or payment may be required)

Water Intake Affects Caloric Intake From Sugary Drinks

TUESDAY, April 23, 2019 (HealthDay News) -- Children who do not drink water have a higher intake of calories from sugar-sweetened beverages (SSBs), according to a study published online April 22 in JAMA Pediatrics.

Abstract/Full Text (subscription or payment may be required)

Individualized Medical-Nutrition Therapy Important in Diabetes

TUESDAY, April 23, 2019 (HealthDay News) -- Diabetes-focused medical nutrition therapy (MNT) is fundamental to overall diabetes management and should be adapted as needed throughout life, according to a consensus report published in the May issue of Diabetes Care.

Abstract/Full Text

Risks, Benefits of Long-Term Drug Therapy for Osteoporosis Reviewed

TUESDAY, April 23, 2019 (HealthDay News) -- Long-term osteoporosis drug therapy (ODT) reduces fracture risk in women but may increase risk for rare adverse events, and research gaps surround use of long-term drug therapies for osteoporotic fracture prevention, according to a review and position paper published online April 23 in the Annals of Internal Medicine.

Abstract/Full Text - Review (subscription or payment may be required)
Abstract/Full Text - Position Paper (subscription or payment may be required)
Editorial (subscription or payment may be required)

Preterm Birth Linked to Periconception HbA1c in T1DM

MONDAY, April 22, 2019 (HealthDay News) -- For women with type 1 diabetes (T1D), the risk for preterm birth is strongly associated with periconceptional hemoglobin A1c (HbA1c) level, according to a study published online April 22 in the Annals of Internal Medicine.

Abstract/Full Text (subscription or payment may be required)

Metformin May Help Obese With Prediabetes Maintain Weight Loss

MONDAY, April 22, 2019 (HealthDay News) -- Metformin is associated with long-term weight loss (LTWL), according to the results of the Diabetes Prevention Program Outcomes Study (DPPOS) published online April 23 in the Annals of Internal Medicine.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Measures May Predict Metabolic Syndrome in Older Adults

MONDAY, April 22, 2019 (HealthDay News) -- Three simple measurements may predict metabolic syndrome (MetS) in older patients, according to a study recently published in Metabolic Syndrome and Related Disorders.

Abstract/Full Text

Atrasentan Tied to Lower Risk for Kidney Events in T2DM With CKD

FRIDAY, April 19, 2019 (HealthDay News) -- Atrasentan is associated with a reduced risk for renal events in patients with type 2 diabetes and chronic kidney disease, according to a study published online April 14 in The Lancet to coincide with the International Society of Nephrology World Congress of Nephrology, held from April 12 to 15 in Melbourne, Australia.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information

National Hand Hygiene Initiative Successful in Australia

FRIDAY, April 19, 2019 (HealthDay News) -- The National Hand Hygiene Initiative (NHHI) has successfully sustained improvement in hand hygiene compliance, according to a study recently published in The Lancet Infectious Diseases and presented at the European Congress of Clinical Microbiology & Infectious Diseases, held from April 13 to 16 in Amsterdam.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information

Acetaminophen Safe as First-Line Analgesic for Most Older Adults

FRIDAY, April 19, 2019 (HealthDay News) -- Despite a potential increased risk for stroke in patients with diabetes, acetaminophen is a safe first-line analgesic for most older adults living in nursing homes, according to a study published online March 26 in the Journal of the American Geriatrics Society.

Abstract/Full Text

Loan Forgiveness, Educational Debt May Affect Practice Patterns

FRIDAY, April 19, 2019 (HealthDay News) -- Increased educational debt appears to directly influence physician practice choice, according to a study published in the April issue of the Journal of the American Osteopathic Association.

Abstract/Full Text

Risk for T2DM Increased With Use of 5α-Reductase Inhibitors

FRIDAY, April 19, 2019 (HealthDay News) -- Men receiving 5α-reductase inhibitors have an increased risk for new-onset type 2 diabetes mellitus, according to a study published online April 11 in The BMJ.

Abstract/Full Text

Sixty People Charged in Massive Opioid Painkiller Investigation

THURSDAY, April 18, 2019 (HealthDay News) -- Fifty-three medical professionals, including 31 doctors, are among the 60 people charged by U.S. authorities for their alleged involvement in the illegal prescribing and distribution of opioid painkillers.

AP News Article

Most Diabetes Phone Apps Lack Education, Support Functions

WEDNESDAY, April 17, 2019 (HealthDay News) -- Most diabetes apps miss opportunities to improve care and health outcomes by not providing real-time decision support or situation-specific education on blood glucose self-management, according to a research letter published in the April 16 issue of the Journal of the American Medical Association.

Abstract/Full Text (subscription or payment may be required)

Sleep Myths Are Commonly Circulated

WEDNESDAY, April 17, 2019 (HealthDay News) -- Commonly held sleep myths have a questionable evidence base, according to a study published online April 16 in Sleep Health.

Abstract/Full Text (subscription or payment may be required)

Mixed Effects Observed for Workplace Wellness Program

TUESDAY, April 16, 2019 (HealthDay News) -- A workplace wellness program improves certain self-reported health behaviors but does not impact clinical measures of health or health care spending, according to a study published in the April 16 issue of the Journal of the American Medical Association.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Low-Carb Breakfast May Improve All-Day Glucose Control in T2DM

TUESDAY, April 16, 2019 (HealthDay News) -- A very low-carbohydrate, high-fat breakfast may be a practical and easy way for patients with type 2 diabetes to lower their overall exposure to postprandial hyperglycemia and improve glycemic variability, according to a study published online April 9 in The American Journal of Clinical Nutrition.

Abstract/Full Text (subscription or payment may be required)

Canagliflozin Seems Effective for Patients With T2DM, Kidney Disease

MONDAY, April 15, 2019 (HealthDay News) -- Canagliflozin is associated with a reduced risk for renal and cardiovascular events for patients with type 2 diabetes and kidney disease, according to a study published online April 14 in the New England Journal of Medicine to coincide with the International Society of Nephrology World Congress of Nephrology, held from April 12 to 15 in Melbourne, Australia.

Abstract/Full Text
Editorial
More Information

Standardizing Demographics Ups Accuracy of Patient Matching

MONDAY, April 15, 2019 (HealthDay News) -- Standardizing demographic data can improve the accuracy of patient matching, according to a study published in the May issue of the Journal of the American Medical Informatics Association.

Abstract/Full Text (subscription or payment may be required)

Added Sugar Labeling Could Reduce CVD, Diabetes Cases

MONDAY, April 15, 2019 (HealthDay News) -- The U.S. Food and Drug Administration policy on added sugar labeling could be a cost-effective way of improving health, according to a study published online April 15 in Circulation.

Abstract/Full Text (subscription or payment may be required)

Gestational Diabetes Linked to Incident Diabetes in Offspring

MONDAY, April 15, 2019 (HealthDay News) -- Gestational diabetes mellitus is associated with incident diabetes in offspring throughout childhood and adolescence, according to a study published online April 15 in CMAJ, the journal of the Canadian Medical Association.

Abstract/Full Text

Metformin May Cut Risk for Prematurity, Miscarriage in PCOS

MONDAY, April 15, 2019 (HealthDay News) -- In pregnant women with polycystic ovary syndrome (PCOS), metformin treatment from the late first trimester until delivery might reduce the risk for late miscarriage and preterm birth but does not prevent gestational diabetes, according to a study published in the April issue of The Lancet Diabetes & Endocrinology.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Colchicine May Improve Obesity-Induced Inflammation

FRIDAY, April 12, 2019 (HealthDay News) -- Colchicine is safe and effective at improving obesity-associated inflammatory measures among adults with obesity and metabolic syndrome (MetS) without diabetes, according to a pilot study published online March 14 in Diabetes, Obesity and Metabolism.

Abstract/Full Text

Domestic Responsibilities Tied to Physician Mothers' Satisfaction

THURSDAY, April 11, 2019 (HealthDay News) -- For physician mothers in procedural specialties, being responsible for five or more domestic tasks is associated with an increased likelihood of career dissatisfaction, according to a study published online April 10 in JAMA Surgery.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

People With Obesity Are Blatantly Dehumanized

WEDNESDAY, April 10, 2019 (HealthDay News) -- People with obesity are not only commonly stigmatized, but are blatantly dehumanized, according to research published online April 2 in Obesity.

Abstract/Full Text

Complication Rates Low for High-Volume Pediatric Thyroid Surgery

WEDNESDAY, April 10, 2019 (HealthDay News) -- Complication rates are low following surgery for pediatric thyroid disease at a high-volume center, according to a study published recently in the Journal of Pediatric Surgery.

Abstract/Full Text (subscription or payment may be required)

FDA Approves Osteoporosis Tx for High-Risk Postmenopausal Women

TUESDAY, April 9, 2019 (HealthDay News) -- Evenity (romosozumab-aqqg) was approved for the treatment of osteoporosis in postmenopausal women with a high risk for fracture, the U.S. Food and Drug Administration announced.

More Information

New, Revised Topics Released in ACR Appropriateness Criteria

TUESDAY, April 9, 2019 (HealthDay News) -- The latest edition of the American College of Radiology (ACR) Appropriateness Criteria has been released and includes 188 diagnostic imaging and interventional radiology topics, with 908 clinical variants covering more than 1,670 clinical scenarios.

More Information

FDA Warns Against Use of Preowned or Unauthorized Test Strips

MONDAY, April 8, 2019 (HealthDay News) -- The U.S. Food and Drug Administration is warning patients not to use preowned test strips or test strips not authorized for sale in the United States because of possible infection or inaccurate results that could cause serious harm.

More Information

Early T2DM Diagnosis Linked to Increased Cardiovascular Risk

MONDAY, April 8, 2019 (HealthDay News) -- The cardiovascular risks associated with type 2 diabetes mellitus (T2DM) are greater for patients diagnosed before age 40 years, according to a study published online April 8 in Circulation.

Abstract/Full Text

Alcohol, Drug Misuse Tied to Long-Term Health Problems

MONDAY, April 8, 2019 (HealthDay News) -- More than one-third of U.S. adults in recovery for alcohol and other drug (AOD) use have health problems related to previous substance use, according to a study published online March 16 in the Journal of Addiction Medicine.

Abstract/Full Text (subscription or payment may be required)

Preventive Drugs Often Used in Last Year of a Cancer Patient's Life

MONDAY, April 8, 2019 (HealthDay News) -- Preventive drugs are frequently used in the last year of life among older adults with cancer, according to a study published online March 25 in Cancer.

Abstract/Full Text (subscription or payment may be required)

Health Issues Prevalent Across BMI Classes for Obese Children

FRIDAY, April 5, 2019 (HealthDay News) -- For children with obesity, physical and mental health issues are highly prevalent, regardless of body mass index (BMI) class, according to a study published online April 2 in The Lancet Child & Adolescent Health.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Female Infertility Specialists Make Less Than Male Specialists

FRIDAY, April 5, 2019 (HealthDay News) -- Although women outnumber men as obstetrician/gynecology clinicians, they still make significantly less money even in subspecialties like reproductive endocrinology and infertility (REI), according to a study published online March 25 in Fertility and Sterility.

Abstract/Full Text (subscription or payment may be required)

Topical Corticosteroids Associated With Higher Risk for Type 2 Diabetes

FRIDAY, April 5, 2019 (HealthDay News) -- There is a positive association between use of topical corticosteroids and incident type 2 diabetes (T2D), according to a study published online April 1 in Diabetes Care.

Abstract/Full Text (subscription or payment may be required)

11 Million Deaths Attributable to Poor Diet in 2017

THURSDAY, April 4, 2019 (HealthDay News) -- Suboptimal diet is associated with increased mortality and morbidity from noncommunicable diseases, according to a study published online April 2 in The Lancet.

Abstract/Full Text
Editorial

Most Osteoporosis Guidelines Do Not Discuss Patient Choices

THURSDAY, April 4, 2019 (HealthDay News) -- Less than 40 percent of osteoporosis clinical practice guidelines include any mention of patients' beliefs, values, or preferences (BVPs), according to a study published online March 11 in Osteoporosis International.

Abstract/Full Text (subscription or payment may be required)

Early Hospital Intervention for Diabetes Improves Outcomes

THURSDAY, April 4, 2019 (HealthDay News) -- Early intervention for patients with diabetes in the hospital decreases hyperglycemia and hospital-acquired infections, according to a study published online March 28 in Diabetes Care.

Abstract/Full Text (subscription or payment may be required)

Short Sleep Duration, Not OSA, Linked to Daytime Sleepiness

THURSDAY, April 4, 2019 (HealthDay News) -- Short sleep duration (SSD) is associated with daytime sleepiness, while obstructive sleep apnea (OSA) is associated with obesity, hypertension, and dyslipidemia, according to a study published online April 1 in CHEST.

Abstract/Full Text (subscription or payment may be required)

New Plan Limits Out-of-Pocket Costs for Insulin

WEDNESDAY, April 3, 2019 (HealthDay News) -- Out-of-pocket costs for insulin could be restricted to $25 a month for people under a drug benefit plan announced Wednesday by Express Scripts.

The New York Times Article

Americans Borrowed $88 Billion in Past Year to Pay for Health Care

TUESDAY, April 2, 2019 (HealthDay News) -- About one in eight Americans borrowed a total of $88 billion in the past year to pay for health care, a new West Health-Gallup survey shows.

CNN Article
West Health-Gallup Survey

Sex Hormone Levels May Impact Development of Asthma

TUESDAY, April 2, 2019 (HealthDay News) -- Sex hormones may impact the risk for asthma, with elevated sex hormone-binding globulin (SHBG) demonstrating a protective effect in females, according to research recently published in Thorax.

Abstract/Full Text

Over-the-Counter Meds Save Health Care System Money

TUESDAY, April 2, 2019 (HealthDay News) -- On average, each dollar spent on over-the-counter (OTC) medicines saves the U.S. health care system $7.20, totaling nearly $146 billion in annual savings, according to a report released March 18 by the Consumer Healthcare Products Association (CHPA).

More Information

Doctors Unclear on Legal Obligations in Caring for Patients With Disability

MONDAY, April 1, 2019 (HealthDay News) -- Practicing physicians might not understand their legal responsibilities when caring for people with disability, which may contribute to inequalities in their care, according to a study published online April 1 in Health Affairs.

Abstract/Full Text (subscription or payment may be required)

Undiagnosed Gestational Diabetes Ups Risk for Stillbirth

MONDAY, April 1, 2019 (HealthDay News) -- Women at risk for gestational diabetes mellitus (GDM) who are not screened or diagnosed are more likely to experience stillbirth than women who undergo screening, according to a study published online March 19 in BJOG, an international journal of obstetrics and gynecology.

Abstract/Full Text

Liquid Meal Replacements Cut Cardiometabolic Risk Factors

MONDAY, April 1, 2019 (HealthDay News) -- Liquid meal replacements in weight loss diets lead to modest reductions in cardiometabolic risk factors for overweight and obese patients with type 2 diabetes, according to a review published online March 28 in Diabetes Care.

Abstract/Full Text (subscription or payment may be required)

Last Updated: