TUESDAY, June 17, 2014 (HealthDay News) -- Treatment of prediabetes and restoration of normal glucose regulation (NGR) reduces cardiovascular risk, according to research presented at the annual meeting of the American Diabetes Association, held from June 13 to 17 in San Francisco.
Leigh Perreault, M.D., of the University of Colorado Denver School of Medicine in Aurora, and colleagues analyzed cardiovascular risk for 2,775 participants in the Diabetes Prevention Program Outcomes Study who were randomly assigned to intensive lifestyle, metformin, or placebo. Cardiovascular risk was assessed by Framingham score and individual risk factors for cardiovascular disease.
The researchers found that Framingham scores according to glycemic exposure did not differ between the groups. During 10 years of follow-up, mean Framingham scores were highest among those in the prediabetes group (16.2 versus 15.2 in those restored to NGR and 14.3 in those with diabetes), but this score declined over time. Higher medication use for treatment of elevated lipid and blood pressure levels partly explained the lower Framingham score in the diabetes group versus the other groups, a declining Framingham score in the pre-diabetes group, and favorable changes in individual cardiovascular risk factors.
"Regardless of type of initial treatment, participants who didn't develop diabetes had a 28 percent lower occurrence of the microvascular complications than those participants who did develop diabetes," a coauthor said in a statement. "These findings show that intervening in the prediabetes phase is important in reducing early stage complications."