Artificial Pancreas Treatment Efficacious for Type 1 Diabetes

Increased time in the near normoglycemic range and reduced time in hypo- and hyperglycemia

Please note: This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. And "More information" links may no longer work. Questions about personal health should always be referred to a physician or other health care professional.

THURSDAY, April 19, 2018 (HealthDay News) -- For patients with type 1 diabetes, artificial pancreas treatment is efficacious, increasing the proportion of time spent in the near normoglycemic range, according to a study published online April 18 in The BMJ.

Eleni Bekiari, M.D., Ph.D., from the University of Thessaloniki in Greece, and colleagues conducted a systematic review and meta-analysis to examine the efficacy and safety of artificial pancreas treatment in non-pregnant outpatients with type 1 diabetes. Forty randomized controlled trials with 1,027 participants and data for 44 comparisons were analyzed.

The researchers found that 35 of the comparisons examined a single-hormone artificial pancreas system, while nine assessed a dual-hormone system. A low risk of bias was seen in only nine studies. Artificial pancreas use was associated with a significantly higher proportion of time in the near normoglycemic range, both overnight (weighted mean difference, 15.15 percent) and over a 24-hour period (9.62 percent). A favorable effect was seen with the artificial pancreas system for the proportion of time with sensor glucose level above 10 mmol/L or below 3.9 mmol/L over 24 hours compared with control treatment (−8.52 and −1.49 percent, respectively). Sensitivity analyses verified the robustness of the findings.

"Artificial pancreas systems are an efficacious and safe approach for treating outpatients with type 1 diabetes," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical device industries.

Abstract/Full Text

Last Updated: