October 2019 Briefing - Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for October 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Juul Shipped Tainted Products, Lawsuit Alleges

THURSDAY, Oct. 31, 2019 (HealthDay News) -- Nearly 1 million tainted nicotine pods were knowingly distributed by electronic cigarette maker Juul Labs, a former company finance executive claims in a lawsuit.

AP News Article

Early Infectious Diseases Consult May Lower Sepsis Mortality

THURSDAY, Oct. 31, 2019 (HealthDay News) -- Early infectious diseases (ID) consultation is associated with a reduction in in-hospital mortality for patients receiving a severe sepsis and septic shock (SS/SS) treatment bundle, according to a study published online Oct. 31 in Open Forum Infectious Diseases.

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Acute Kidney Injury Often Seen With Checkpoint Inhibitor Use

THURSDAY, Oct. 31, 2019 (HealthDay News) -- Patients receiving checkpoint inhibitor therapy often have acute kidney injury (AKI), according to a study published online Oct. 31 in the Clinical Journal of the American Society of Nephrology.

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Gilteritinib Superior in Relapsed, Refractory FLT3-Mutated AML

THURSDAY, Oct. 31, 2019 (HealthDay News) -- For relapsed or refractory acute myeloid leukemia (AML) with mutations in the FMS-like tyrosine kinase 3 gene (FLT3), treatment with a selective FLT3 inhibitor, gilteritinib, results in significantly longer survival and a greater percentage of patients with remission than salvage chemotherapy, according to a study published in the Oct. 31 issue of the New England Journal of Medicine.

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No Benefit Seen for SLNB in BCS for DCIS in Older Women

THURSDAY, Oct. 31, 2019 (HealthDay News) -- For older patients with ductal carcinoma in situ (DCIS) who undergo breast-conserving surgery (BCS), sentinel lymph node biopsy (SLNB) is not associated with improvements in long-term outcomes, according to a study published in the December issue of JNCI Cancer Spectrum.

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Bariatric Surgery Linked to Reduced Risk for Skin Cancer

THURSDAY, Oct. 31, 2019 (HealthDay News) -- For individuals with obesity, bariatric surgery is associated with a reduced risk for skin cancer, including melanoma, according to a study published online Oct. 30 in JAMA Dermatology.

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J&J Says No Asbestos Detected in New Tests of Baby Powder

WEDNESDAY, Oct. 30, 2019 (HealthDay News) -- No asbestos was detected in 15 new tests of the same bottle of Johnson & Johnson's Baby Powder previously found to contain asbestos by the U.S. Food and Drug Administration, the company said Tuesday.

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Survey Reveals Many Americans Lack Cancer Prevention Knowledge

WEDNESDAY, Oct. 30, 2019 (HealthDay News) -- Only one in four U.S. adults report incorporating cancer prevention into their daily lives, according to the results of the American Society of Clinical Oncology 2019 National Cancer Opinion Survey.

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High Fiber, Yogurt Intake Linked to Reduced Risk for Lung Cancer

WEDNESDAY, Oct. 30, 2019 (HealthDay News) -- Dietary fiber and yogurt consumption are associated with a reduced risk for lung cancer, according to a pooled analysis published online Oct. 24 in JAMA Oncology.

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CDC: U.S. Life Expectancy Up Slightly, Mortality Lower in 2017

WEDNESDAY, Oct. 30, 2019 (HealthDay News) -- Life expectancy has increased slightly in the United States, and mortality is lower than in 2007, according to a report published Oct. 30 by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.

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FDA Labeling Restriction Quickly Reflected in Oncology Practice

TUESDAY, Oct. 29, 2019 (HealthDay News) -- The June 2018 U.S. Food and Drug Administration label restriction on first-line immunotherapy for advanced bladder cancer was associated with a decrease in immunotherapy use and an increase in chemotherapy use, according to a research letter published in the Sept. 24 issue of the Journal of the American Medical Association.

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Cancer Screening Rates Lower Among Women With Diabetes

TUESDAY, Oct. 29, 2019 (HealthDay News) -- Women with diabetes have lower rates of breast, cervical, and colorectal cancer screening compared with women without diabetes, according to a review published online Oct. 24 in Diabetologia.

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Facebook Launches Preventive Health Tool

TUESDAY, Oct. 29, 2019 (HealthDay News) -- A new tool designed to help guide preventive care for heart disease, cancer, and seasonal flu was launched in the United States Monday by Facebook.

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Childhood Cancer Treatment Increases Risk for Breast Cancer Later

TUESDAY, Oct. 29, 2019 (HealthDay News) -- The combination of anthracyclines and radiotherapy doses to treat childhood cancer is associated with an increased risk for subsequent breast cancer, according to a study published online Oct. 28 in JAMA Pediatrics.

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Outcomes Poor With Medical Care From Fraud, Abuse Perpetrators

MONDAY, Oct. 28, 2019 (HealthDay News) -- Receiving medical care from fraud and abuse perpetrators (FAPs), subsequently excluded from Medicare, is associated with higher rates of all-cause mortality and emergency hospitalization, according to a study published online Oct. 28 in JAMA Internal Medicine.

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SunSmart Program Ups Sun Protection Behaviors

MONDAY, Oct. 28, 2019 (HealthDay News) -- A skin cancer prevention program -- "SunSmart" -- can create lasting changes in sun protection behavior and contribute to the decline in melanoma rates, according to a study published online Oct. 8 in PLOS Medicine.

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Predictors of Immune Response to Hep B Shot ID'd in Lymphoma

MONDAY, Oct. 28, 2019 (HealthDay News) -- For patients with lymphoma, the dose and frequency of hepatitis B vaccination, sex, Ann Arbor stage, and ibrutinib as part of the chemotherapy regimen are independent factors that affect the impact of the vaccine, according to a study published online Oct. 16 in Leukemia & Lymphoma.

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Delay of Surgery for DCIS Ups Risk for Invasive Breast Cancer

FRIDAY, Oct. 25, 2019 (HealthDay News) -- For each month of delay between diagnosis and surgery for ductal carcinoma in situ (DCIS), there is slightly worse survival and an increase in risk for invasive disease, according to a study published online Sept. 27 in the Annals of Surgical Oncology.

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AI Model Based on US Classifies Thyroid Nodules by Genetic Risk

FRIDAY, Oct. 25, 2019 (HealthDay News) -- A model developed through automated machine learning uses ultrasonographic images to classify indeterminate thyroid nodules as having low or high genetic risk, according to a study published online Oct. 24 in JAMA Otolaryngology-Head & Neck Surgery.

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Google Searches for CBD Up Substantially

THURSDAY, Oct. 24, 2019 (HealthDay News) -- Interest in cannabidiol (CBD) across the United States has increased considerably and is accelerating, according to a research letter published online Oct. 23 in JAMA Network Open.

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FDA: N.J. Company Must Stop Selling Unapproved Flavored Vaping Products

THURSDAY, Oct. 24, 2019 (HealthDay News) -- Eonsmoke LLC has been ordered to halt illegal sales of 100 unapproved flavored vaping products in the United States, the U.S. Food and Drug Administration says.

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Prediagnosis Exercise May Reduce CV Risk in Breast Cancer

THURSDAY, Oct. 24, 2019 (HealthDay News) -- For women with primary breast cancer, prediagnosis exercise exposure is associated with a graded reduction in subsequent cardiovascular event (CVE) risk, according to a study published in the September issue of JACC: CardioOncology.

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FDA May Put Strong Warning on Breast Implants

WEDNESDAY, Oct. 23, 2019 (HealthDay News) -- Before receiving breast implants, women should be told of the possible risks, the U.S. Food and Drug Administration says in a draft proposal.

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FDA: Smokeless Tobacco Snus Can Be Marketed as Less Risky Than Cigarettes

WEDNESDAY, Oct. 23, 2019 (HealthDay News) -- U.S. health groups are slamming the U.S. Food and Drug Administration's decision to permit the General brand of the smokeless tobacco product snus to claim that it poses a "lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema, and chronic bronchitis" than cigarettes.

CNN Article
More Information: FDA

Poor Health Literacy Tied to More Hardships Among Cancer Survivors

WEDNESDAY, Oct. 23, 2019 (HealthDay News) -- Health insurance literacy may be an important intervention for addressing financial problems associated with cancer, according to a study published online Oct. 21 in JNCI Cancer Spectrum.

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First Use of Flavored Tobacco Linked to Subsequent Use

WEDNESDAY, Oct. 23, 2019 (HealthDay News) -- First use of a flavored tobacco product is associated with increased risk for subsequent tobacco use, according to a study published online Oct. 23 in JAMA Network Open.

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Outcomes Across Nonmelanoma Skin Cancer Treatments Similar

WEDNESDAY, Oct. 23, 2019 (HealthDay News) -- Outcomes for nonmelanoma skin cancers are similar at one year, regardless of treatment type, although cosmetic results vary, according to a review published in the Oct. 15 issue of Cancer.

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More Choices, Lower Premiums for ACA Consumers Next Year

TUESDAY, Oct. 22, 2019 (HealthDay News) -- There will be more health insurance choices and a slight decrease in premiums for many consumers next year under the Affordable Care Act, according to the Trump administration.

AP News Article

Expert Second Opinions Up Reliability of Melanoma Diagnosis

TUESDAY, Oct. 22, 2019 (HealthDay News) -- Second opinions rendered by dermatopathologists improve the reliability of melanocytic lesion diagnosis, although there is still discordance among pathologists, according to a study published online Oct. 11 in JAMA Network Open.

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Personal Colorectal Cancer Risk Should Drive Screening

TUESDAY, Oct. 22, 2019 (HealthDay News) -- Using the GRADE system to review new evidence, a panel issued weak recommendations for colorectal cancer screening options based on estimated 15-year individual risk, according to a clinical practice guideline published online Oct. 2 in The BMJ.

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Life-Gained Selection Maximizes Lung Cancer Screening Benefits

MONDAY, Oct. 21, 2019 (HealthDay News) -- Selection of ever-smokers for lung cancer screening based on gains in life expectancy can increase total life expectancy from screening but prevents fewer lung cancer deaths, according to a study published online Oct. 22 in the Annals of Internal Medicine.

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Recommendations Updated for Nonvariceal Upper GI Bleeding

MONDAY, Oct. 21, 2019 (HealthDay News) -- In clinical guidelines published online Oct. 22 in the Annals of Internal Medicine, updated recommendations are presented for the management of nonvariceal upper gastrointestinal bleeding.

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Exercise Intolerance May Harm Neurocognition in ALL Survivors

MONDAY, Oct. 21, 2019 (HealthDay News) -- For adult survivors of childhood acute lymphoblastic leukemia (ALL), exercise intolerance is associated with worse neurocognitive outcomes, according to a study published online Oct. 21 in Cancer.

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Johnson & Johnson Recalls Baby Powder Due to Presence of Asbestos

FRIDAY, Oct. 18, 2019 (HealthDay News) -- A shipment of baby powder has been recalled by Johnson & Johnson after U.S. authorities found asbestos in it.

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Use of E-Cigarettes in U.K. Tied to Quit Rates Among Smokers

FRIDAY, Oct. 18, 2019 (HealthDay News) -- Electronic cigarette use in England is positively associated with overall cigarette quit rates and quit success rates, according to a study published online Oct. 17 in Addiction.

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Risk for Secondary Primary Cancer Varies With Lymphoma Stage

FRIDAY, Oct. 18, 2019 (HealthDay News) -- The risk for secondary primary malignancies (SPMs) varies based on stage of diffuse large B-cell lymphoma (DLBCL) at diagnosis, according to a study published online Sept. 11 in Cancer.

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Patient Cost Responsibility Up for Guideline-Discordant Care

FRIDAY, Oct. 18, 2019 (HealthDay News) -- For patients with metastatic breast cancer (MBC), receipt of National Comprehensive Cancer Network Guideline-discordant care is associated with higher patient cost responsibility, according to a study published in the October issue of the Journal of the National Comprehensive Cancer Network.

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Juul Stopping Sales of Fruit, Dessert Flavors of E-Cigarettes

THURSDAY, Oct. 17, 2019 (HealthDay News) -- Juul, which makes the top-selling brand of electronic cigarettes in the United States, said Thursday it will no longer sell fruit or dessert flavors of its products. The company's decision comes as it faces widespread criticism that its flavored nicotine products are hooking a generation of teenagers on nicotine and vaping, the Associated Press reported Thursday.

AP News Article
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Campaign for Tobacco-Free Kids Statement

Use of Novel Therapy, Stem Cell Transplant in MM Varies by Race

THURSDAY, Oct. 17, 2019 (HealthDay News) -- Different racial/ethnic groups with multiple myeloma (MM) have significant variations in novel therapy and autologous stem cell transplant (ASCT) use, according to a study published online Oct. 17 in Blood Advances.

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Prediagnostic Colonoscopy Cuts Colorectal Cancer Death Risk

THURSDAY, Oct. 17, 2019 (HealthDay News) -- The risk for colorectal cancer death drops with an increasing number of prediagnostic colonoscopies, largely due to fewer advanced cancers at time of diagnosis, according to a study recently published in BMC Cancer.

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Risk for Cancer Incidence, Mortality Increased With Psoriasis

WEDNESDAY, Oct. 16, 2019 (HealthDay News) -- Patients with psoriasis have an increased risk for developing or dying from cancer, according to a review published online Oct. 16 in JAMA Dermatology.

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Meat Study Authors Have Financial Ties to Beef Industry

TUESDAY, Oct. 15, 2019 (HealthDay News) -- The authors of a recent study downplaying the health risks of red meat have financial ties with meat producers. The international group of researchers has received funding from a university program partially backed by the beef industry, the Washington Post reported Monday.

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Washington Post Article

Pulmonary Embolism Risk Elevated for More Than Six Weeks Postop

TUESDAY, Oct. 15, 2019 (HealthDay News) -- The postoperative risk for pulmonary embolism extends more than six weeks for six types of surgery, according to a study published online Oct. 9 in JAMA Surgery.

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Rates of Head, Neck Melanoma Up in North American Youth

TUESDAY, Oct. 15, 2019 (HealthDay News) -- From 1995 to 2014, there was a 51.1 percent increase in the incidence of pediatric, adolescent, and young adult head and neck melanoma in North America, according to a study published online Oct. 3 in JAMA Otolaryngology-Head & Neck Surgery.

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Study Compares Anticoagulants for Antiphospholipid Syndrome

TUESDAY, Oct. 15, 2019 (HealthDay News) -- In thrombotic antiphospholipid antibody syndrome (APS), rivaroxaban is not noninferior to dose-adjusted vitamin K antagonists (VKAs), according to a study published online Oct. 15 in the Annals of Internal Medicine.

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Nearly 5 Million Youth Are Obese in the United States

FRIDAY, Oct. 11, 2019 (HealthDay News) -- Nationwide, 4.8 million young people ages 10 to 17 years have obesity, according to the State of Childhood Obesity: Helping All Children Grow Up Healthy report published Oct. 10 by the Robert Wood Johnson Foundation.

State of Childhood Obesity: Helping All Children Grow Up Healthy

Patient Portal Use Has Positive Impact on Preventive Health Behaviors

FRIDAY, Oct. 11, 2019 (HealthDay News) -- Patient portal use has a positive impact on preventive health behaviors, but not on chronic health outcomes, according to a study published in the October issue of the Journal of Medical Internet Research.

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Ibrutinib Therapy Linked to New, Worsened Hypertension

FRIDAY, Oct. 11, 2019 (HealthDay News) -- Ibrutinib is associated with an increased risk for new or worsened hypertension in patients treated for B-cell malignancies, according to a study published online Oct. 3 in Blood.

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Effects on Quality of Life Mixed for Tx of Multiple Myeloma

FRIDAY, Oct. 11, 2019 (HealthDay News) -- Most dimensions of quality of life (QoL) are impaired in patients with relapsed/refractory multiple myeloma, and treatment may have mixed effects on QoL, according to a study published online Sept. 26 in Leukemia & Lymphoma.

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Multigene Testing for All Breast Cancer Patients Cost-Effective

THURSDAY, Oct. 10, 2019 (HealthDay News) -- Unselected, multigene testing for all patients with breast cancer would be cost-effective in the United Kingdom and the United States, according to a study published online Oct. 3 in JAMA Oncology.

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Medicare Fraud-Prevention Rules to Be Revised

WEDNESDAY, Oct. 9, 2019 (HealthDay News) -- Revision of decades-old Medicare rules meant to prevent fraud has been proposed by the Trump administration.

AP News Article

2000 to 2015 Saw Increase in Medicare GME Payments

WEDNESDAY, Oct. 9, 2019 (HealthDay News) -- Medicare graduate medical education (GME) payments increased significantly from 2000 to 2015, according to a study published online Oct. 7 in JAMA Internal Medicine.

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Foreign-Born Women in U.S. Less Likely to Have Mammograms

WEDNESDAY, Oct. 9, 2019 (HealthDay News) -- Regardless of the percentage of lifetime spent in the United States, foreign-born women are less likely to ever have received a mammogram compared with U.S.-born women, according to the Oct. 9 National Health Statistics Reports, a publication from the U.S. Centers for Disease Control and Prevention.

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American Indians, Alaska Natives Have Higher Cancer Incidence

WEDNESDAY, Oct. 9, 2019 (HealthDay News) -- The U.S. American Indian and Alaska Native (AI/AN) population faces a higher risk for many cancers than white Americans living in the same geographical region, according to a study published in the October issue of Cancer Epidemiology, Biomarkers & Prevention.

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Cost of Waste in U.S. Health System Estimated

TUESDAY, Oct. 8, 2019 (HealthDay News) -- The estimated cost of waste in the U.S. health care system varies from $760 to $935 billion, according to a special communication published online Oct. 7 in the Journal of the American Medical Association.

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Burnout Linked to Poor Quality Care in Published Literature

TUESDAY, Oct. 8, 2019 (HealthDay News) -- In the published literature, burnout in health care professionals is frequently associated with poor-quality care, but the effect size may be smaller than reported, according to data from a systematic review published online Oct. 8 in the Annals of Internal Medicine.

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PARP Inhibitor Slows Progression of Advanced Ovarian Cancer

TUESDAY, Oct. 8, 2019 (HealthDay News) -- The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor veliparib plus platinum-based chemotherapy for induction therapy, followed by maintenance therapy with veliparib, improves progression-free survival (PFS) in the initial treatment of high-grade serous ovarian carcinoma, according to a study published online Sept. 28 in the New England Journal of Medicine. The research was published to coincide with the European Society of Medical Oncology Congress 2019, held from Sept. 27 to Oct. 1 in Barcelona, Spain.

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Hysterectomy Technique Tied to Poorer Uterine Cancer Outcomes

MONDAY, Oct. 7, 2019 (HealthDay News) -- Uncontained power morcellation is associated with a higher mortality risk in women with occult uterine sarcoma, especially in those with occult leiomyosarcoma, according to a study published online Sept. 16 in the Journal of Clinical Oncology.

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Indoor Tanning May Up Risk for Squamous Cell Carcinoma

MONDAY, Oct. 7, 2019 (HealthDay News) -- There is a dose-response association between indoor tanning and risk for cutaneous squamous cell carcinoma in women, according to a study published online Oct. 2 in JAMA Dermatology.

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Treatment of Male Breast Cancer Has Evolved From 2004 to 2014

MONDAY, Oct. 7, 2019 (HealthDay News) -- Treatment of male breast cancer (MBC) has evolved since 2004, with increases in various treatment modalities, according to a study published online Oct. 7 in Cancer.

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Few Older European Men Aware of Prostate Function

FRIDAY, Oct. 4, 2019 (HealthDay News) -- A new survey shows that older men have low awareness about prostate health and function, according to a study commissioned by the European Association of Urology (EAU).

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Survey: Many U.S. Adults Not Planning to Get Flu Vaccine

FRIDAY, Oct. 4, 2019 (HealthDay News) -- Many U.S. adults, including some at the highest risk for the flu and pneumonia, do not plan to get preventive vaccines, according to a survey conducted by NORC at the University of Chicago on behalf of the National Foundation for Infectious Diseases.

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Considerable Proportion of ICU Admissions May Be Preventable

FRIDAY, Oct. 4, 2019 (HealthDay News) -- A considerable proportion of intensive care unit (ICU) admissions may be preventable, according to a study published online Oct. 4 in the Annals of the American Thoracic Society.

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With Comorbidities, Less Than Six Hours of Sleep Ups Risk for Early Death

FRIDAY, Oct. 4, 2019 (HealthDay News) -- Middle-aged adults with high blood pressure, type 2 diabetes, heart disease, or stroke could be at higher risk for cancer and early death when sleeping less than six hours per day, according to a study published online Oct. 2 in the Journal of the American Heart Association.

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2014 to 2018 Saw Drop in Flavored Tobacco Products in Youth

THURSDAY, Oct. 3, 2019 (HealthDay News) -- From 2014 to 2018, there was a decrease in current use of one or more flavored tobacco products among youth, according to research published in the Oct. 4 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Factors Predict Low BMD in Pediatric Blood Cancer Survivors

THURSDAY, Oct. 3, 2019 (HealthDay News) -- Low bone mineral density (BMD) is common in childhood leukemia and lymphoma survivors, according to a study published online Sept. 19 in Cancer.

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Risk Calculator Can Help Predict Postmenopausal Morbidity

THURSDAY, Oct. 3, 2019 (HealthDay News) -- A new risk prediction calculator can make health risk predictions for several outcomes simultaneously in postmenopausal women, according to a study published online Sept. 16 in Menopause.

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PTSD Symptoms Tied to Higher Risk for Ovarian Cancer

THURSDAY, Oct. 3, 2019 (HealthDay News) -- Posttraumatic stress disorder (PTSD) symptoms are associated with an increased risk for ovarian cancer, especially among premenopausal women, according to a study published online Sept. 5 in Cancer Research.

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Breast Cancer Mortality Rate Continues to Decline in the U.S.

WEDNESDAY, Oct. 2, 2019 (HealthDay News) -- The breast cancer death rate is continuing to decline, although the decline has slowed in recent years, according to a report published online Oct. 2 in CA: A Cancer Journal for Clinicians.

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Care at High-Volume Facility May Cut Mortality in Multiple Myeloma

WEDNESDAY, Oct. 2, 2019 (HealthDay News) -- Patients with multiple myeloma (MM) may receive a survival benefit from being treated at high-volume facilities, according to a study published in the September issue of the Journal of the National Comprehensive Cancer Network.

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No Benefit Found for High-Dose Vitamin C Infusions in Sepsis, ARDS

TUESDAY, Oct. 1, 2019 (HealthDay News) -- Compared with placebo, intravenous infusion of high-dose vitamin C does not improve organ dysfunction or alter markers of inflammation or vascular injury among patients with sepsis and acute respiratory distress syndrome (ARDS), according to a study published in the Oct. 1 issue of the Journal of the American Medical Association.

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Incidence of HPV-Positive Head and Neck Cancer Up in the U.S.

TUESDAY, Oct. 1, 2019 (HealthDay News) -- The rate of head and neck cancers has risen since the 1970s, and most cases are linked to human papillomavirus (HPV), according to a study recently published in Cancer Epidemiology, Biomarkers & Prevention.

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