September 2019 Briefing - Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for September 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Panel Votes Yes to Current Level of Red, Processed Meat Intake

MONDAY, Sept. 30, 2019 (HealthDay News) -- An international panel suggests that adults continue their current levels of consumption of red or processed meat based on evidence from five systematic reviews published online Oct. 1 in the Annals of Internal Medicine.

Clinical Guideline
Review 1
Review 2
Review 3
Review 4
Review 5
Editorial

Rivaroxaban Cuts Recurrent Blood Clots in Obese Patients

MONDAY, Sept. 30, 2019 (HealthDay News) -- Real-world evidence shows that rivaroxaban reduces the risk for recurrent venous thromboembolism (VTE) in morbidly obese patients, with similar safety and efficacy as warfarin, according to a study published in the October issue of Thrombosis Research.

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Low Cancer Suspicion Tied to Delay in CRC Referral in Primary Care

MONDAY, Sept. 30, 2019 (HealthDay News) -- Delay in referral for colorectal cancer (CRC) in primary care is associated with low cancer suspicion, according to a study published in the September/October issue of Annals of Family Medicine.

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Editorial

ASCO: More Than One in Five Millennials Use E-Cigarettes

FRIDAY, Sept. 27, 2019 (HealthDay News) -- One in eight U.S. adults report using electronic cigarettes regularly, according to the American Society of Clinical Oncology's 2019 Cancer Opinions Survey.

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SBRT Shortens Tx for Prostate Cancer Without Greater Toxicity

FRIDAY, Sept. 27, 2019 (HealthDay News) -- A targeted radiotherapy technique can substantially cut treatment time for prostate cancer without increasing gastrointestinal or genitourinary acute toxicity, according to a phase 3 study published online Sept. 17 in The Lancet Oncology.

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Average Annual Premium for Workers Increased in 2019

THURSDAY, Sept. 26, 2019 (HealthDay News) -- In 2019, the average annual health insurance premium for workers increased slightly for single coverage and family coverage, according to a report published online Sept. 25 in Health Affairs.

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Prostate Cancer Risk Higher in Men Receiving Fertility Treatment

THURSDAY, Sept. 26, 2019 (HealthDay News) -- Men fathering children through assisted reproduction techniques rather than natural conception have an increased risk for prostate cancer, including early-onset disease, according to a study published online Sept. 25 in The BMJ.

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Deep Learning Models Classify Disease From Medical Imaging

THURSDAY, Sept. 26, 2019 (HealthDay News) -- Early evidence suggests that diagnostic performance of deep learning models is equivalent to that of health care professionals for interpreting medical imaging, according to a study published online Sept. 25 in The Lancet Digital Health.

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Editorial

Severe Adverse Cardiovascular Events Associated With Ibrutinib

THURSDAY, Sept. 26, 2019 (HealthDay News) -- Cardiovascular adverse drug reactions (CV-ADR) occur in association with ibrutinib, according to a study published in the Oct. 1 issue of the Journal of the American College of Cardiology.

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Editorial (subscription or payment may be required)

Mohs Micrographic Surgery May Up Survival in Stage I Melanoma

THURSDAY, Sept. 26, 2019 (HealthDay News) -- Mohs micrographic surgery (MMS) is associated with improved survival compared with traditional surgery with wide margin excision (WME) for stage I melanoma, according to a study published online Sept. 25 in JAMA Dermatology.

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Blast Count Prognostic for CML Presenting in Advanced Phase

THURSDAY, Sept. 26, 2019 (HealthDay News) -- Blast count seems to be the main prognostic count for patients with chronic myeloid leukemia (CML) presenting in an advanced phase, according to a study published online Aug. 27 in the American Journal of Hematology.

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E-Cigarette Maker Juul Stops All Advertising, Replaces CEO

WEDNESDAY, Sept. 25, 2019 (HealthDay News) -- Amid a national outbreak of vaping-linked illnesses and deaths, vape device maker Juul Labs said Wednesday it is stopping all print, digital, and television advertising, and its CEO, Kevin Burns, is stepping down.

AP News Article

Incidence of Hodgkin Lymphoma Up in Least Deprived Areas

WEDNESDAY, Sept. 25, 2019 (HealthDay News) -- Individuals living in the most affluent areas of the United Kingdom seem to have an increased incidence of Hodgkin lymphoma (HL), according to a study published in the August issue of BMJ Open.

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Racial/Ethnic Disparities in Mortality Persist in the U.S.

WEDNESDAY, Sept. 25, 2019 (HealthDay News) -- There are still racial and ethnic disparities in mortality, and these disparities are widening for some age groups, according to a study published online Sept. 24 in the American Journal of Preventive Medicine.

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Quality of Carbohydrates, Protein Has Improved in U.S. Diet

WEDNESDAY, Sept. 25, 2019 (HealthDay News) -- From 1999 to 2016, the percentage of energy intake from low-quality carbohydrates decreased and that from high-quality carbohydrates and plant protein increased, according to a study published in the Sept. 24 issue of the Journal of the American Medical Association.

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Percentage of Women in Internal Med Residencies Increasing

TUESDAY, Sept. 24, 2019 (HealthDay News) -- From 1999 to 2016, the percentage of women in internal medicine residencies increased, but the percentage in subspecialty fellowships decreased, according to a research letter published online Sept. 23 in JAMA Internal Medicine.

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Behavioral Treatment Helps Reduce Insomnia in Cancer Survivors

TUESDAY, Sept. 24, 2019 (HealthDay News) -- A stepped care approach seems beneficial for insomnia treatment among cancer survivors, according to a study published online Sept. 24 in Cancer.

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High-Intensity Surveillance of Colorectal Adenomas Modeled

MONDAY, Sept. 23, 2019 (HealthDay News) -- For patients with colorectal adenomas, high-intensity surveillance could provide modest benefits over low-intensity surveillance, at an acceptable cost, according to a study published online Sept. 24 in the Annals of Internal Medicine.

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Protected Health Info Breaches Compromise Sensitive Data

MONDAY, Sept. 23, 2019 (HealthDay News) -- Most protected health information (PHI) breaches compromise sensitive demographic and/or financial information, according to a research letter published online Sept. 23 in the Annals of Internal Medicine.

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Higher Mortality Seen for Male Breast Cancer Patients

MONDAY, Sept. 23, 2019 (HealthDay News) -- Male breast cancer patients have higher mortality after cancer diagnosis than female patients, according to a study published online Sept. 19 in JAMA Oncology.

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Timely Palliative Care After Lung Cancer Diagnosis May Up Survival

MONDAY, Sept. 23, 2019 (HealthDay News) -- For patients with advanced lung cancer, palliative care is associated with increased survival when it is received 31 to 365 days after cancer diagnosis, according to a study published online Sept. 19 in JAMA Oncology.

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Editorial (subscription or payment may be required)

Marijuana Use Common Among Adults With Medical Conditions

FRIDAY, Sept. 20, 2019 (HealthDay News) -- Marijuana use is common among adults with medical conditions, especially younger people, according to a study published online Sept. 20 in JAMA Network Open.

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House Speaker Unveils Plan to Lower Drug Costs

THURSDAY, Sept. 19, 2019 (HealthDay News) -- House Speaker Nancy Pelosi has revealed a plan to lower the cost of medications for people on Medicare and those with private insurance.

AP News Article

Medical Students Not Ready to Provide Nutritional Care

THURSDAY, Sept. 19, 2019 (HealthDay News) -- Medical education does not equip students to provide high-quality, effective nutrition care, according to a review published in the September issue of The Lancet Planetary Health.

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Editorial

ASTRO Issues Guideline for Radiation Tx in Pancreatic Cancer

THURSDAY, Sept. 19, 2019 (HealthDay News) -- In a new American Society for Radiation Oncology clinical practice guideline, published in the September-October issue of Practical Radiation Oncology, recommendations are presented for radiation treatment of pancreatic cancer.

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Skipping Cancer Referral Appointments Linked to Earlier Death

THURSDAY, Sept. 19, 2019 (HealthDay News) -- Cancer diagnosis is less likely in patients not attending referral appointments for suspected cancer, but these patients have worse early mortality outcomes than attending patients, according to a study published online Sept. 11 in Cancer Epidemiology.

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Anemia in Early Pregnancy May Harm Child Neurodevelopment

WEDNESDAY, Sept. 18, 2019 (HealthDay News) -- Anemia diagnosed during the first 30 weeks of pregnancy is associated with an increased risk for autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID), according to a study published online Sept. 18 in JAMA Psychiatry.

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Electronic Nose Analysis May Predict Response to Anti-PD-1 Therapy in NSCLC

WEDNESDAY, Sept. 18, 2019 (HealthDay News) -- For patients with non-small cell lung cancer (NSCLC), responders and nonresponders can be differentiated by a metal oxide semiconductor electronic nose (eNose) analysis of exhaled breath before starting antiprogrammed death ligand 1 (anti-PD-1) therapy, according to a study published online Sept. 17 in the Annals of Oncology.

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Nonphysician Providers Rarely Interpret Diagnostic Images

WEDNESDAY, Sept. 18, 2019 (HealthDay News) -- Despite increasing roles of nonphysician providers (NPPs) in health care (nurse practitioners and physician assistants), they still rarely interpret diagnostic imaging studies, according to a study published online Sept. 11 in the American Journal of Roentgenology.

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Many Older Patients With AML Not Receiving Active Treatment

WEDNESDAY, Sept. 18, 2019 (HealthDay News) -- Many older patients with acute myeloid leukemia (AML) do not receive any active treatment, and they have worse survival than those receiving active treatment, according to a study published online Sept. 4 in Cancer.

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Pulegone Levels in Mint, Menthol E-Cigarettes May Be Unsafe

TUESDAY, Sept. 17, 2019 (HealthDay News) -- Users of mint- and menthol-flavored electronic cigarettes and smokeless tobacco are exposed to pulegone levels higher than what the U.S. Food and Drug Administration considers acceptable for intake of synthetic pulegone in food, according to a research letter published online Sept. 16 in JAMA Internal Medicine.

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Initiating Empirical Tx for Sepsis Reduces Blood Culture Sensitivity

TUESDAY, Sept. 17, 2019 (HealthDay News) -- When empirical antimicrobial therapy is initiated in patients with severe manifestations of sepsis, the sensitivity of blood cultures drawn shortly after treatment initiation is reduced, according to a study published online Sept. 17 in the Annals of Internal Medicine.

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Men Less Knowledgeable About HPV, HPV Vaccination

TUESDAY, Sept. 17, 2019 (HealthDay News) -- Men are less knowledgeable than women about human papillomavirus (HPV), HPV vaccination, and the correlation between HPV and cancer, according to a research letter published online Sept. 16 in JAMA Pediatrics.

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Screening for Breast Cancer in Men Has Increased Over Time

TUESDAY, Sept. 17, 2019 (HealthDay News) -- Screening for breast cancer in men has increased over time, with high sensitivity and specificity for mammographic screening, according to a study published online Sept. 17 in Radiology.

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Delaying Treatment Worsens Head, Neck Cancer Outcomes

MONDAY, Sept. 16, 2019 (HealthDay News) -- Delaying time to treatment initiation (TTI) beyond 60 days is associated with decreased overall survival and increased head and neck cancer recurrence, according to a study published online Sept. 12 in JAMA Otolaryngology-Head & Neck Surgery.

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Editorial (subscription or payment may be required)

Room for Improvement Found in HPV Vaccine Delivery Practices

MONDAY, Sept. 16, 2019 (HealthDay News) -- There are areas for improvement for pediatricians and family physicians (FPs) in recommendation and delivery methods for the human papillomavirus (HPV) vaccine, according to a study published online Sept. 16 in Pediatrics.

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Nine States Now Have an Obesity Rate Above 35 Percent

THURSDAY, Sept. 12, 2019 (HealthDay News) -- The number of U.S. states with adult obesity rates above 35 percent reached an all-time high of nine in 2018, according to the Trust for America's Health, the nonprofit group behind the 16th annual "State of Obesity: Better Policies for a Healthier America" report.

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H. Pylori Treatment May Reduce Gastric Cancer Incidence, Death

THURSDAY, Sept. 12, 2019 (HealthDay News) -- Helicobacter pylori treatment, vitamin supplementation, and garlic supplementation are associated with a reduced risk for gastric cancer mortality, according to a study published online Sept. 11 in The BMJ.

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Intrauterine Device Use May Reduce Incidence of Ovarian Cancer

THURSDAY, Sept. 12, 2019 (HealthDay News) -- Intrauterine device (IUD) use among reproductive women is associated with a decreased incidence of ovarian cancer, according to a review published online Sept. 10 in Obstetrics & Gynecology.

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Cancer Survival Increasing in High-Income Countries

THURSDAY, Sept. 12, 2019 (HealthDay News) -- Cancer survival is continuing to increase across high-income countries, although there are international disparities, according to a study published online Sept. 11 in The Lancet Oncology.

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EPA to Phase Out Chemical Testing on Mammals

WEDNESDAY, Sept. 11, 2019 (HealthDay News) -- The eventual elimination of chemical testing on mammals was announced Tuesday by the U.S. Environmental Protection Agency.

The New York Times Article
More Information: EPA

Spending Up With Treatment in Hospital-Owned Practices

WEDNESDAY, Sept. 11, 2019 (HealthDay News) -- Financial integration between physicians and hospitals raises patient spending but does not impact care quality, according to a study published online Sept. 3 in the Journal of General Internal Medicine.

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Guideline Updated for Screening, Surveillance of Barrett Esophagus

WEDNESDAY, Sept. 11, 2019 (HealthDay News) -- In a guideline published in the September issue of Gastrointestinal Endoscopy, updated recommendations are presented for screening and surveillance among patients with Barrett esophagus (BE).

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Full Chemo Doses May Improve Survival in Breast Cancer

WEDNESDAY, Sept. 11, 2019 (HealthDay News) -- Maintaining full doses of chemotherapy, especially early in the treatment course, is important for survival of intermediate or high-risk breast cancer patients, according to a study published in the August issue of the Journal of the National Comprehensive Cancer Network.

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Poverty Rate Drops, but Fewer Americans Have Health Insurance

TUESDAY, Sept. 10, 2019 (HealthDay News) -- The percentage of Americans living in poverty declined in 2018, but the rate of those without health insurance increased, according to a U.S. Census Bureau report.

The New York Times Article
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Herd Protection Against Oral HPV Infections Seen Among Men

TUESDAY, Sept. 10, 2019 (HealthDay News) -- In unvaccinated men aged 18 to 59 years, the prevalence of vaccine-type oral human papillomavirus (HPV) decreased between 2009 to 2010 and 2015 to 2016, according to a research letter published in the Sept. 10 issue of the Journal of the American Medical Association.

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Malnutrition Common in Older Brazilians Hospitalized for Cancer

TUESDAY, Sept. 10, 2019 (HealthDay News) -- The prevalence of malnutrition is high among older, Brazilian patients hospitalized for cancer, according to a study published online Sept. 9 in Cancer.

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1,125,000 Men/Boys Expected to Have Hemophilia Worldwide

TUESDAY, Sept. 10, 2019 (HealthDay News) -- The expected number of patients with hemophilia worldwide is 1,125,000 male patients, with 418,000 severe cases, according to research published online Sept. 10 in the Annals of Internal Medicine.

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FDA Warns Juul About Illegal Marketing Claims, Pitch to Youth

MONDAY, Sept. 9, 2019 (HealthDay News) -- A warning letter has been sent to Juul Labs Inc. about illegal claims that its electronic cigarettes are safer than tobacco cigarettes, including statements made in a presentation to students, the U.S. Food and Drug Administration says.

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T2DM Risk Reduced by 75 Percent With Healthiest Lifestyle

MONDAY, Sept. 9, 2019 (HealthDay News) -- Individuals with the healthiest lifestyle have a 75 percent reduced risk for type 2 diabetes, and those with diabetes have a lower risk for mortality, according to a review published online Sept. 4 in Diabetologia.

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Mammos May Not Benefit Elderly Women With Chronic Illness

FRIDAY, Sept. 6, 2019 (HealthDay News) -- For older women, the cumulative incidence of death from other causes is many times higher than breast cancer incidence and death, according to a study published online Sept. 6 in the Journal of the National Cancer Institute.

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Incidence of Colorectal Cancer Up in Younger Adults Worldwide

FRIDAY, Sept. 6, 2019 (HealthDay News) -- Among younger adults, colorectal cancer (CRC) incidence rates have increased in several countries, according to a study published online Sept. 5 in Gut.

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Racial, Ethnic Underrepresentation Found in Med School Matriculants

FRIDAY, Sept. 6, 2019 (HealthDay News) -- Among medical school matriculants, black, Hispanic, and American Indian or Alaska Native (AIAN) students are underrepresented, according to a study published online Sept. 4 in JAMA Network Open.

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Majority of U.S. Doctors Believe ACA Has Improved Access to Care

THURSDAY, Sept. 5, 2019 (HealthDay News) -- Sixty percent of U.S. physicians believe that the Affordable Care Act (ACA) has improved access to care and insurance after five years of implementation, according to a report published in the September issue of Health Affairs.

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Algorithm Based on Response, Biology Guides Neuroblastoma Tx

THURSDAY, Sept. 5, 2019 (HealthDay News) -- Use of a response- and biology-based treatment algorithm for intermediate-risk neuroblastoma is associated with excellent survival and reduces treatment for some patients, according to a study published online Aug. 6 in the Journal of Clinical Oncology.

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Drinking Soft Drinks Tied to Higher Risk for Early Death

WEDNESDAY, Sept. 4, 2019 (HealthDay News) -- Greater consumption of soft drinks, both sugar-sweetened and artificially sweetened, is associated with a higher risk for all-cause mortality, according to a European study published online Sept. 3 in JAMA Internal Medicine.

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Low-Fat Dietary Pattern Offers Long-Term Health Benefits

WEDNESDAY, Sept. 4, 2019 (HealthDay News) -- A low-fat dietary pattern provides lasting health benefits, according to a study published in the September issue of The Journal of Nutrition.

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USPSTF Advises Meds to Reduce Risk for Primary Breast Cancer

TUESDAY, Sept. 3, 2019 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians offer risk-reducing medications to women at increased risk for breast cancer and at low risk for adverse medication effects. These recommendations form the basis of a final recommendation statement published in the Sept. 3 issue of the Journal of the American Medical Association.

Final Recommendation Statement
Evidence Report
Editorial 1 (subscription or payment may be required)
Editorial 2 (subscription or payment may be required)

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