April 2018 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for April 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Review: Need to Strengthen Natural Experiments in Obesity

MONDAY, April 30, 2018 (HealthDay News) -- Based on findings from a systematic review of the literature, recommendations have been developed for improving the evidence for natural experiments in obesity; the review and position paper were published online May 1 in the Annals of Internal Medicine.

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Similar Risk Predicted for Automated, Clinical BI-RADS Density

MONDAY, April 30, 2018 (HealthDay News) -- Automated and clinical Breast Imaging Reporting and Data System (BI-RADS) density measures similarly predict breast cancer risk, according to a study published online May 1 in the Annals of Internal Medicine.

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Five Healthy Lifestyle Habits Could Add >10 Years to Life

MONDAY, April 30, 2018 (HealthDay News) -- Adopting a healthy lifestyle, with five low-risk lifestyle factors is associated with increased life expectancy, according to a study published online April 30 in Circulation.

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Liver-Kidney Recipients Have Donor-Specific Hypo-Responses

MONDAY, April 30, 2018 (HealthDay News) -- Simultaneous liver-kidney transplant recipients' peripheral blood cells have unique phenotypic and functional characteristics that are associated with donor-specific hypo-alloresponsiveness, according to a study published online April 12 in Kidney International.

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CCHD Newborn Screening May Detect Other Diseases

MONDAY, April 30, 2018 (HealthDay News) -- Critical congenital heart disease (CCHD) newborn screening detects a low percentage of new cases of CCHD, but it can detect other important diseases, according to a study published online April 24 in Pediatrics.

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ALS by Physician May Improve Traumatic Arrest Outcomes

FRIDAY, April 27, 2018 (HealthDay News) -- For patients with traumatic out-of-hospital cardiac arrest (OHCA), pre-hospital advanced life support (ALS) provided by a physician is associated with increased likelihood of one-month survival, according to a study published online April 25 in JAMA Surgery.

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Spermatogenesis Still Occurs in Men With Testicular Cancer

FRIDAY, April 27, 2018 (HealthDay News) -- Spermatogenesis occurs in most men with testicular cancer, often away from tumors, according to a study published online April 17 in BJU International.

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Sickle Cell Trait Not Linked to Stroke in African-Americans

FRIDAY, April 27, 2018 (HealthDay News) -- For African-Americans, sickle cell trait (SCT) seems not to be associated with the incidence of ischemic stroke, according to a meta-analysis published online April 23 in JAMA Neurology.

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Improvement in Race-Based Disparities in Years of Life Lost

THURSDAY, April 26, 2018 (HealthDay News) -- From 1990 to 2014 there was a decrease in race-based disparities in years of life lost (YLL) in the United States, according to a study published online April 25 in PLOS ONE.

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Multiple Myeloma Risk May Be Up for WTC-Exposed Firefighters

THURSDAY, April 26, 2018 (HealthDay News) -- World Trade Center-exposed firefighters have increased prevalence of monoclonal gammopathy of undetermined significance (MGUS) and light-chain MGUS, which are precursors to multiple myeloma, as well as an increased cancer burden, according to two studies published online April 26 in JAMA Oncology.

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Fetal Inflammation May Play Role in Preterm Labor

WEDNESDAY, April 25, 2018 (HealthDay News) -- Fetal inflammation and rejection of maternal antigens is associated with uterine contractility and aberrant fetal immune responses, which may play a role in preterm labor (PTL), according to a study published in the April 25 issue of Science Translational Medicine.

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Medicare Requiring Hospitals to Post Prices Online

WEDNESDAY, April 25, 2018 (HealthDay News) -- U.S. hospitals will have to post their standard prices online and make it easier for patients to access their electronic medical records, Medicare officials said Tuesday.

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IBD Associated With Increased Incidence of Parkinson's Disease

WEDNESDAY, April 25, 2018 (HealthDay News) -- Patients with inflammatory bowel disease (IBD) have increased incidence of Parkinson's disease (PD), which is attenuated with anti-tumor necrosis factor (TNF) therapy, according to a study published online April 23 in JAMA Neurology.

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Increase in HTN in Children Based on 2017 AAP Guidelines

WEDNESDAY, April 25, 2018 (HealthDay News) -- The prevalence and severity of high blood pressure (BP) in children have increased based on the 2017 American Academy of Pediatrics clinical practice guidelines, according to a study published online April 23 in JAMA Pediatrics.

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Aortic Stiffness, Concentric LV Remodeling Linked in T2DM

WEDNESDAY, April 25, 2018 (HealthDay News) -- For patients with type 2 diabetes, aortic stiffness is associated with concentric left ventricular (LV) remodeling, according to a study published online April 16 in Diabetes.

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Preteens Metabolically Comparable to Trained Athletes

TUESDAY, April 24, 2018 (HealthDay News) -- Prepubertal children are metabolically comparable to adult endurance athletes, and less fatiguable with high intensity exercise than untrained adults, according to a study published online April 24 in the Frontiers in Physiology.

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Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

TUESDAY, April 24, 2018 (HealthDay News) -- There is a linear correlation for physical activity (PA) with amyotrophic lateral sclerosis (ALS), according to a study published online April 23 in the Journal of Neurology, Neurosurgery & Psychiatry.

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Alcohol Intake May Influence Oral Microbiome Composition

TUESDAY, April 24, 2018 (HealthDay News) -- Alcohol consumption, specifically heavy drinking, may influence the oral microbiome composition, according to a study published online April 24 in Microbiome.

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Black Men More Likely to Die From Firearm Homicide

TUESDAY, April 24, 2018 (HealthDay News) -- Firearm homicides are much more common among black men compared to white men, particularly in rust belt states, according to a study published online April 24 in the Annals of Internal Medicine.

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Factors ID'd to Predict Fatty Liver in Obese Teens

MONDAY, April 23, 2018 (HealthDay News) -- Ethnicity/race, markers of insulin resistance, and genetic factors might help identify obese youth at risk for developing fatty liver, according to a study published online April 17 in Hepatology.

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Cancer Screening More Likely After a Previous False Positive

MONDAY, April 23, 2018 (HealthDay News) -- Patients who previously had a false-positive breast or prostate cancer screening test result are more likely to have future screenings, according to a study published online April 23 in Cancer.

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Grip Strength Indicative of Cognition in Major Depression

MONDAY, April 23, 2018 (HealthDay News) -- For individuals with major depression and bipolar disorder, grip strength is positively associated with cognition, according to a study published online April 18 in JAMA Psychiatry.

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Questions Surround Concept of Internet Gaming Disorder

FRIDAY, April 20, 2018 (HealthDay News) -- The concept of internet gaming disorder (IGD) and the pathways leading to it are unclear, according to a review published online April 6 in Developmental Medicine & Child Neurology.

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High FGF-23 Linked to Recurrent Cardiac Events After ACS

FRIDAY, April 20, 2018 (HealthDay News) -- Elevated fibroblast growth factor 23 (FGF-23) is associated with increased risk of recurrent major cardiovascular (CV) events in patients after an acute coronary syndrome (ACS), according to a study published online April 18 in JAMA Cardiology.

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Annual Visits May Not Increase Cognitive Impairment Detection

FRIDAY, April 20, 2018 (HealthDay News) -- Medicare Annual Wellness Visits (AWVs) do not appear to substantially increase the detection of cognitive impairment in older adults, according to a study published online April 2 in the Journal of the American Geriatrics Society.

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In LVSD, Diabetes Tied to Higher Risk of Heart Failure

FRIDAY, April 20, 2018 (HealthDay News) -- In patients with asymptomatic left ventricular systolic dysfunction, diabetes is associated with an increased risk of developing heart failure, according to a study published online April 6 in Diabetes Care.

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Gene Therapy Found to Be Promising for β-Thalassemia

THURSDAY, April 19, 2018 (HealthDay News) -- For patients with severe β-thalassemia, the need for red-cell transfusions can be reduced or eliminated by transducing cells with the LentiGlobin BB305 vector, according to a study published in the April 18 issue of the New England Journal of Medicine.

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Cellular Biomedical Tattoo Can ID Hypercalcemia-Linked Cancer

WEDNESDAY, April 18, 2018 (HealthDay News) -- A cell-based biomedical tattoo can detect hypercalcemia associated with cancer in a murine model, according to an experimental study published in the April 18 issue of Science Translational Medicine.

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Mild TBI May Increase Risk of Parkinson's Disease

WEDNESDAY, April 18, 2018 (HealthDay News) -- Mild traumatic brain injury (TBI) is associated with increased risk of Parkinson's disease (PD) among military veterans, according to a study published online April 18 in Neurology.

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Young Adults With T1DM Show Muscle Metabolic Deficiencies

WEDNESDAY, April 18, 2018 (HealthDay News) -- Physically active young adults with type 1 diabetes have alterations in mitochondrial ultrastructure and bioenergetics within skeletal muscle, according to a study published online April 18 in Diabetologia.

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Males With BRCA Mutations Have Increased Risk of Certain Cancers

TUESDAY, April 17, 2018 (HealthDay News) -- Males with BRCA mutations have increased incidence of malignant disease, specifically prostate, melanoma, pancreas, and breast cancers, according to a research letter published online April 12 in JAMA Oncology.

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Recommendations Developed on Gender Equity in Medicine

MONDAY, April 16, 2018 (HealthDay News) -- In a position paper published online April 17 in the Annals of Internal Medicine, recommendations are provided aimed at addressing gender equity in physician compensation and career advancement opportunities.

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TFs Operate Across Gene Loci Within Disease Phenotypes

MONDAY, April 16, 2018 (HealthDay News) -- Transcription factors (TFs) seem to operate across gene loci, according to a study published online April 16 in Nature Genetics.

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Increased Pollution Exposure Ups Health Care Visits for Acute URI

MONDAY, April 16, 2018 (HealthDay News) -- Short-term exposure to fine particulate matter (PM2.5) is associated with increased health care utilization for acute lower respiratory infection (ALRI), according to a study published online April 13 in the American Journal of Respiratory and Critical Care Medicine.

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Volumetric Laser Endomicroscopy Helps ID Barrett's Regions

MONDAY, April 16, 2018 (HealthDay News) -- Volumetric laser endomicroscopy (VLE) users can identify regions of interest for potential Barrett's esophagus (BE) dysplasia with a high degree of agreement, according to a study published online April 6 in the Journal of Gastroenterology and Hepatology.

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Nonoptimized Drug Therapy Costs More Than $500 Billion Annually

MONDAY, April 16, 2018 (HealthDay News) -- The estimated annual cost of drug-related morbidity and mortality resulting from nonoptimized medication therapy is more than half a trillion dollars in the United States, according to a study published online March 26 in the Annals of Pharmacotherapy.

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One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

MONDAY, April 16, 2018 (HealthDay News) -- One- and two-hour plasma glucose concentrations (1h-PG and 2h-PG, respectively) are similarly effective at predicting diabetic retinopathy (DR), according to a study published online April 5 in Diabetes Care.

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Negative Affect That Lingers Tied to Health 10 Years Later

FRIDAY, April 13, 2018 (HealthDay News) -- Negative affect that lingers is associated with worse physical health outcomes almost 10 years later, according to a study published online March 19 in Psychological Science.

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Negative Fateful Life Events Linked to Advanced Brain Aging

THURSDAY, April 12, 2018 (HealthDay News) -- Negative fateful life events (FLEs) in midlife are associated with advanced predicted brain aging, according to a study published in the July issue of Neurobiology of Aging.

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Recent Years Saw Increase in Burden of Prior Authorization

THURSDAY, April 12, 2018 (HealthDay News) -- The burden of prior authorization (PA) has increased over the past five years, and 92 percent of physicians report associated delays in access to care, according to the results of a survey published by the American Medical Association (AMA).

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Quality of Life Predicts Mortality in Older Breast Cancer Patients

THURSDAY, April 12, 2018 (HealthDay News) -- For older women with early-stage breast cancer, measures of health-related quality of life (HRQOL) predict 10-year mortality independently of traditional breast cancer prognostic variables, according to a study published online March 13 in the Journal of the American Geriatrics Society.

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Higher Mortality Risk Seen for 'Night Owls'

THURSDAY, April 12, 2018 (HealthDay News) -- Individuals with a later chronotype have increased mortality risk, according to a study published online April 12 in Chronobiology International.

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ZIKV RNA Often ID'd in Semen of Men With Symptomatic Infection

WEDNESDAY, April 11, 2018 (HealthDay News) -- Zika virus (ZIKV) RNA is frequently present in the semen of men with symptomatic ZIKV infection and can persist for over six months, according to a study published in the April 12 issue of the New England Journal of Medicine.

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Metabolic Syndrome Common in Patients With Lupus

TUESDAY, April 10, 2018 (HealthDay News) -- As with the general population, metabolic syndrome (MetS) is common among patients with systemic lupus erythematosus (SLE), according to a study published online April 3 in the International Journal of Rheumatic Diseases.

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Suggestions Offered to Reduce Physician Frustration With EHRs

TUESDAY, April 10, 2018 (HealthDay News) -- Changes can be implemented to help reduce physician frustration with electronic health records (EHRs), according to an article published in Medical Economics.

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Considerable Differences in Burden of Disease at State Level

TUESDAY, April 10, 2018 (HealthDay News) -- There are considerable differences in the burden of disease at the state level, according to a study published in the April 10 issue of the Journal of the American Medical Association.

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One Night of Sleep Deprivation Linked to Amyloid-β Burden

TUESDAY, April 10, 2018 (HealthDay News) -- One night of sleep deprivation is associated with amyloid-β (Aβ) burden (ABB) in healthy controls, according to a study published online April 9 in the Proceedings of the National Academy of Sciences.

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Exercise Best Defense for Those at Genetic Risk for CVD

TUESDAY, April 10, 2018 (HealthDay News) -- Fitness and physical activity are tied to lower risk of incident cardiovascular disease in the general population and among individuals with elevated genetic risk for cardiovascular diseases, according to a study published online April 9 in Circulation.

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White Matter Tracts Differ for Infants With Fragile X Syndrome

MONDAY, April 9, 2018 (HealthDay News) -- There are significant differences in the development of 12 fiber tracts between infants with fragile X syndrome (FXS) and controls, according to a study published online April 4 in JAMA Psychiatry.

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Interns' Schedule Takes Toll on Sleep, Physical Activity, Mood

FRIDAY, April 6, 2018 (HealthDay News) -- New interns' intense and changing schedules take a toll on sleep, activity, and mood, according to a study published online March 14 in the Journal of General Internal Medicine.

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Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

FRIDAY, April 6, 2018 (HealthDay News) -- Myocarditis in patients treated with immune checkpoint inhibitors (ICIs) may be more common than previously thought, according to a study published online March 19 in the Journal of the American College of Cardiology.

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Leukemia, and Its Treatment, May Pose Neurocognitive Risks

FRIDAY, April 6, 2018 (HealthDay News) -- Underlying leukemia, even before chemotherapy, may pose a neurocognitive risk to young patients, according to a study published online March 29 in JAMA Oncology.

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Glycemic Extremes in T1DM Impact Cognitive Skills in Kids

FRIDAY, April 6, 2018 (HealthDay News) -- Type 1 diabetes is associated with cognitive dysfunction in children, according to a review published online March 23 in the Journal of Diabetes Investigation.

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ACA Marketplaces Expand Coverage for Chronically Ill

THURSDAY, April 5, 2018 (HealthDay News) -- The Affordable Care Act's Marketplaces covered a disproportionate share of non-elderly adults with high health care risks in the 2014 to 2015 time period, according to a study published in the April issue of Health Affairs.

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Preserved Neurogenesis in Hippocampus of Healthy Seniors

THURSDAY, April 5, 2018 (HealthDay News) -- Healthy older subjects display preserved neurogenesis, according to a study published in the April 5 issue of Cell Stem Cell.

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Coffee Consumption Cuts Coronary Artery Calcification

THURSDAY, April 5, 2018 (HealthDay News) -- There is an inverse association between coffee consumption and coronary artery calcium (CAC), especially among never smokers, according to a study published online March 24 in the Journal of the American Heart Association.

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mRNA Assay Less Sensitive Than DNA Assay for Latent HPV

THURSDAY, April 5, 2018 (HealthDay News) -- The human papillomavirus (HPV) mRNA assays are less sensitive than HPV DNA assays for detection of latent HPV infection, according to a study published online March 8 in Obstetrics & Gynecology.

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Early-Life Epilepsy Should Be Urgently Treated With EBM

WEDNESDAY, April 4, 2018 (HealthDay News) -- Early-life epilepsy should be treated with the same urgency as pediatric cancer, according to an article published online April 4 in Neurology.

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Metabolic Abnormalities Seen in Testicular Cancer Survivors

WEDNESDAY, April 4, 2018 (HealthDay News) -- Testicular cancer survivors (TCS) have metabolic abnormalities characterized by hypertension and increased low-density lipoprotein (LDL) and total cholesterol, according to a study published in the March 1 issue of the Journal of the National Comprehensive Cancer Network.

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Breast Cancer Diagnosis, Therapy Differ in Women With Implants

WEDNESDAY, April 4, 2018 (HealthDay News) -- Method of diagnosis, stage, and treatment are not affected by type of breast implant or anatomic location, according to research published in the April issue of Plastic and Reconstructive Surgery.

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CDC: Aggressive Action Needed to Contain Antibiotic Resistance

WEDNESDAY, April 4, 2018 (HealthDay News) -- Early aggressive action should be taken to prevent the spread of bacteria harboring unusual resistance genes, according to a report published April 3 by the U.S. Centers for Disease Control and Prevention.

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Most Parents Willing to Enroll Child in Food Allergen Trials

TUESDAY, April 3, 2018 (HealthDay News) -- The majority of caregivers of children with food allergy are willing to consider participation in clinical trials for food allergy immunotherapy, according to a research letter published in the March issue of the Annals of Allergy, Asthma & Immunology.

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Genotype-Guided Antiplatelet Therapy Feasible, Effective

TUESDAY, April 3, 2018 (HealthDay News) -- Using CYP2C19 genotype-guided dual antiplatelet therapy (DAPT) selection is feasible in a real-world setting, although frequency of testing may be difficult to maintain, according to a study published online April 3 in Circulation: Genomic and Precision Medicine.

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Anomalous Brain Structure ID'd in Preschoolers With ADHD

TUESDAY, April 3, 2018 (HealthDay News) -- Anomalous brain development is evident among medication-naive preschoolers with attention-deficit/hyperactivity disorder (ADHD), according to a study published in the April issue of the Journal of the International Neuropsychological Society.

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Overweight, Obesity Contributing to Cancers in Young Adults

TUESDAY, April 3, 2018 (HealthDay News) -- Overweight and obesity may be contributing to specific malignancies at younger ages, according to research published online March 23 in Obesity.

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apoE Aggregation May Impact apoE-Mediated Plaque Formation

MONDAY, April 2, 2018 (HealthDay News) -- A primary mechanism for APOE gene (apoE)-mediated plaque formation may result from apoE aggregation, according to a study published online March 30 in the Journal of Clinical Investigation.

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Zika Vaccine Could Essentially Eliminate Prenatal Infection

MONDAY, April 2, 2018 (HealthDay News) -- A Zika vaccine could substantially prevent future outbreaks through a combination of direct protection and indirect transmission reduction, according to a modeling study published online April 3 in the Annals of Internal Medicine.

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Infant Heart Defects May Be Early Marker of Future CVD in Mothers

MONDAY, April 2, 2018 (HealthDay News) -- Women whose infants have congenital heart defects have an increased risk of cardiovascular hospitalization later in life, according to a study published online April 2 in Circulation.

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Grief Symptoms Similar in Donor vs Non-Donor Decision Families

MONDAY, April 2, 2018 (HealthDay News) -- Perceptions of the organ donation experience vary between relatives who decide to donate their relative's organs and those who do not, but the decision does not appear to be associated with subsequent grief symptoms, according to a study published online March 19 in the American Journal of Respiratory and Critical Care Medicine.

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