August 2019 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for August 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

CDC Boosts Efforts to Fight Congo Ebola Outbreak

FRIDAY, Aug. 30, 2019 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention has stepped up its efforts to help fight the Ebola outbreak in the Democratic Republic of the Congo (DRC).

More Information: CDC
CBS News Article

NFL Seasons of Play, Playing Position Affect Mental Health

FRIDAY, Aug. 30, 2019 (HealthDay News) -- For football players in the National Football League, seasons of play and playing position are associated with lasting neuropsychiatric health deficits, according to a study published online Aug. 30 in the American Journal of Sports Medicine.

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Plasma Marker May Help Detect Traumatic Brain Injury

THURSDAY, Aug. 29, 2019 (HealthDay News) -- Plasma concentration of glial fibrillary acidic protein (GFAP) can aid in detecting traumatic brain injury (TBI) by identifying patients with negative findings on computed tomography (CT) scan who might need magnetic resonance imaging (MRI) and additional follow-up, according to a study published online Aug. 23 in The Lancet Neurology.

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Editorial (subscription or payment may be required)

1984 to 2016 Saw Increase in Age of Death for HIV-Infected

THURSDAY, Aug. 29, 2019 (HealthDay News) -- The mean age at death increased for patients with HIV infection from 1984 to 2016, according to a study published online Aug. 28 in the Archives of Pathology & Laboratory Medicine.

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USPSTF Advises Broader Age Range for Hep C Screening

TUESDAY, Aug. 27, 2019 (HealthDay News) -- The U.S. Preventive Services Task Force recommends hepatitis C virus (HCV) infection screening for individuals aged 18 to 79 years. These recommendations form the basis of a draft recommendation statement published online Aug. 27 by the USPSTF.

Draft Recommendation Statement
Draft Evidence Review
Comment on Recommendations

WHO: Malaria Eradication Not Currently Possible

FRIDAY, Aug. 23, 2019 (HealthDay News) -- The eradication of malaria worldwide may eventually be possible, but when that might be achieved is unclear, according to the World Health Organization.

AP News Article
More Information: WHO

Prevalence of Celiac Disease High in First-Degree Relatives

FRIDAY, Aug. 23, 2019 (HealthDay News) -- The prevalence of celiac disease is higher among screened first-degree relatives (FDRs) of patients with celiac disease, according to a study published online Aug. 22 in the Mayo Clinic Proceedings.

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Private Rooms Help Sustain Lower Rates of Some Nosocomial Colonization

WEDNESDAY, Aug. 21, 2019 (HealthDay News) -- A hospital's move to entirely single-patient rooms was associated with reductions in multidrug-resistant organism colonization, according to a study published online Aug. 19 in JAMA Internal Medicine.

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High, Increasing BP in Midlife Tied to Brain Changes in Late Life

WEDNESDAY, Aug. 21, 2019 (HealthDay News) -- There appears to be a correlation for high and increasing blood pressure (BP) from early adulthood and into midlife with white matter hyperintensity volume (WMHV) and smaller brain volumes at age 69 to 71 years, according to a study published online Aug. 21 in The Lancet Neurology.

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Editorial

Exposure to Air Pollutants May Up Risk for Macular Degeneration

WEDNESDAY, Aug. 21, 2019 (HealthDay News) -- Chronic exposure to high levels of nitrogen dioxide (NO2) and carbon monoxide (CO) is associated with an increased risk for age-related macular degeneration (AMD) in a population in Taiwan, according to a study published online Aug. 19 in the Journal of Investigative Medicine.

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USPSTF Recommends Genetic Counseling for High BRCA Risk

TUESDAY, Aug. 20, 2019 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends that women who are at increased risk for BRCA1/2 mutations should undergo genetic counseling, and if indicated, genetic testing. These recommendations form the basis of a final recommendation statement published in the Aug. 20 issue of the Journal of the American Medical Association.

Recommendation Statement
Evidence Report
Editorial 1 (subscription or payment may be required)
Editorial 2 (subscription or payment may be required)
Editorial 3 (subscription or payment may be required)
Editorial 4 (subscription or payment may be required)

Exposure to Pollution May Up Risk for Psychiatric Disorders

TUESDAY, Aug. 20, 2019 (HealthDay News) -- Environmental pollution appears to be associated with an increased risk for psychiatric disorders, especially bipolar disorder and major depression, according to a report published online Aug. 20 in PLOS Biology.

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Editorial

MRI Shows Vaping Has Transient Impact on Vascular Function

TUESDAY, Aug. 20, 2019 (HealthDay News) -- In healthy nonsmokers, inhaling nicotine-free electronic cigarette aerosol has a transient impact on endothelial function, according to a study published online Aug. 20 in Radiology.

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Recommendations Developed for Management of Lyme Disease

FRIDAY, Aug. 16, 2019 (HealthDay News) -- The Infectious Diseases Society of America, the American Academy of Neurology, and the American College of Rheumatology have released a draft of their joint clinical practice guidelines for the management of Lyme disease.

Draft Guidelines
Draft Supplemental Materials
Comment on Guidelines

AI Program May Aid in Pathologic Evaluation of Breast Biopsies

FRIDAY, Aug. 16, 2019 (HealthDay News) -- An artificial intelligence program outperforms pathologists for differentiating ductal carcinoma in situ (DCIS) from atypia, according to a study published online Aug. 9 in JAMA Network Open.

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Advertising Can Promote Interest in Health-Related Research

THURSDAY, Aug. 15, 2019 (HealthDay News) -- Advertising current local health-related research using large TV monitors in emergency department waiting rooms can increase the short-term interest in health-related research, according to a study published online Aug. 1 in BMJ Open.

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Renal Anomaly on Fetal Scan May Up Risk for Admission for Child

THURSDAY, Aug. 15, 2019 (HealthDay News) -- Renal pelvis dilatation (RPD) at the fetal anomaly scan (FAS) and persistent dilatation in later pregnancy or postpartum is associated with an increased risk for hospital admission in early childhood, according to a study published online July 31 in PLOS Medicine.

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Internet Self-Referrals Aid in Diagnosis of Rare Inherited Kidney Disease

WEDNESDAY, Aug. 14, 2019 (HealthDay News) -- A considerable proportion of families diagnosed at an autosomal dominant tubulointerstitial kidney disease specialist center are the result of direct family referral from the internet, according to a study published online July 24 in Genetics in Medicine.

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Gluten Intake, Celiac Disease Linked in Genetically Predisposed

WEDNESDAY, Aug. 14, 2019 (HealthDay News) -- For children at increased risk, increased gluten intake during the first five years of life is associated with an elevated incidence of celiac disease autoimmunity and celiac disease, according to a study published in the Aug. 13 issue of the Journal of the American Medical Association.

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Editorial (subscription or payment may be required)

TSH Elevated in 6 Percent of Psychiatrically Hospitalized Youth

WEDNESDAY, Aug. 14, 2019 (HealthDay News) -- About 6 percent of psychiatrically hospitalized youth have abnormal thyroid-stimulating hormone (TSH) measures, according to a study published online Aug. 6 in the Journal of Clinical Psychiatry.

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Doctors Say New Drugs 'Cured' Two Ebola Patients

TUESDAY, Aug. 13, 2019 (HealthDay News) -- New drugs cured two Ebola patients in Congo, showing that people can recover from the highly lethal disease if it is diagnosed and treated early, doctors say.

AP News Article

Methylphenidate Tx Tied to Brain Changes in Boys With ADHD

TUESDAY, Aug. 13, 2019 (HealthDay News) -- Treatment with methylphenidate (MPH) affects specific tracts in brain white matter in boys with attention-deficit/hyperactivity disorder (ADHD), according to a study published online Aug. 13 in Radiology.

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CVD Mortality Declines Are Slowing in High-Income Countries

TUESDAY, Aug. 13, 2019 (HealthDay News) -- High-income countries have experienced a recent slowing in the cardiovascular disease (CVD) mortality decline, according to a study published online Aug. 5 in the International Journal of Epidemiology.

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Adherence to Surgical Guidelines Low for Salpingo-Oophorectomy

MONDAY, Aug. 12, 2019 (HealthDay News) -- Only two-thirds of all health care providers are fully adherent to surgical guidelines for risk-reducing salpingo-oophorectomy, according to a study published online Aug. 7 in Obstetrics & Gynecology.

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One-Third of Physicians Will Take 10+ Years to Pay Off Debt

MONDAY, Aug. 12, 2019 (HealthDay News) -- Nearly two-thirds of actively practicing physicians are still carrying medical school debt, according to the Medical School Debt Report 2019, published by the staffing firm Weatherby Healthcare.

Medical School Debt Report 2019

New Ebola Drugs Highly Effective, Might Shorten Outbreak in Africa

MONDAY, Aug. 12, 2019 (HealthDay News) -- Two experimental Ebola treatments have worked so well in the Democratic Republic of Congo outbreak that they will be offered to all patients, scientists say.

The New York Times Article

EPA Will Not Approve Warning Labels for Glyphosate

MONDAY, Aug. 12, 2018 (HealthDay News) -- Warning labels for the suspected cancer-causing weed killer glyphosate (Roundup) will not be approved by the U.S. Environmental Protection Agency.

AP News Article

Method to Calculate Central Line Infections Flawed

FRIDAY, Aug. 9, 2019 (HealthDay News) -- Using the true number of central lines as the denominator improves methods of determining central line-associated bloodstream infection (CLABSI) rates, according to a study published online July 24 in Infection Control & Hospital Epidemiology.

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Giant Cell Arteritis Occurs at Similar Rate in Blacks, Whites

FRIDAY, Aug. 9, 2019 (HealthDay News) -- Biopsy-proven giant cell arteritis (BP-GCA) occurs at a similar rate among white and black patients, according to a study published online Aug. 8 in JAMA Ophthalmology.

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Medicare to Cover CAR-T Therapy for Leukemia, Lymphoma

THURSDAY, Aug. 8, 2019 (HealthDay News) -- A breakthrough gene therapy will be covered for certain types of lymphoma and leukemia, Medicare says.

AP News Article

Hematological Malignancy Risk Up for First-Degree Relatives

THURSDAY, Aug. 8, 2019 (HealthDay News) -- First-degree relatives of patients with hematological malignancies have increased relative risks for the same tumor types and some different hematological malignancies, according to a study published online Aug. 8 in Blood.

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Younger CRC Patients More Likely to Present With Abdominal Pain

THURSDAY, Aug. 8, 2019 (HealthDay News) -- Younger patients with colorectal cancer are more likely to present with abdominal pain and via an emergency, according to a study published online Aug. 6 in Colorectal Disease.

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Some Cancer Trends Differ for Oldest Old in the United States

WEDNESDAY, Aug. 7, 2019 (HealthDay News) -- Some cancer trends differ for U.S. patients aged 85 years and older, according to a study published online Aug. 7 in CA: A Cancer Journal for Clinicians.

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USPSTF Reaffirms Recs Against Screening for Pancreatic Cancer

TUESDAY, Aug. 6, 2019 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends against screening for pancreatic adenocarcinoma as the potential benefits do not outweigh the potential harms. These recommendations form the basis of a final recommendation statement published in the Aug. 6 issue of the Journal of the American Medical Association.

Recommendation Statement
Evidence Report
Editorial 1
Editorial 2

DNA Methylation Classifier Predicts Progression in CIN2

TUESDAY, Aug. 6, 2019 (HealthDay News) -- A DNA methylation classifier can predict progression in young women with untreated cervical intraepithelial neoplasia grade 2 (CIN2), according to a study published online July 25 in Clinical Infectious Diseases.

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Children With ADHD Have Differences in Part of Brain Controlling Movement

TUESDAY, Aug. 6, 2019 (HealthDay News) -- Children with attention-deficit/hyperactivity disorder (ADHD) may have differences in the brain that limit appropriate responses to "stop cues," according to a study published online July 17 in Neurology.

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Neuropathology Tied to Dementia ID'd in Football Players Who Had CTE

MONDAY, Aug. 5, 2019 (HealthDay News) -- White matter rarefaction, arteriolosclerosis, and dorsolateral frontal cortex (DLFC) neurofibrillary tangles (NFTs) are independently associated with dementia among older men who played football and had chronic traumatic encephalopathy (CTE), according to a study published online Aug. 5 in JAMA Neurology.

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Editorial (subscription or payment may be required)

Plasma Assay Promising for Diagnosis of Early Alzheimer Disease

FRIDAY, Aug. 2, 2019 (HealthDay News) -- Plasma β-amyloid (Aβ)42/Aβ40 corresponds with amyloid positron emission tomography (PET) status, according to a study published online Aug. 1 in Neurology.

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First Ebola Transmission in Congo City of Goma Reported

THURSDAY, Aug. 1, 2019 (HealthDay News) -- The first transmission of the Ebola virus in Congo's major city of Goma was announced Thursday by the country's health ministry. It said that the disease has been confirmed in the 1-year-old daughter of a man who died of Ebola on Wednesday. The man had symptoms for several days while at home with his large family, CBS News reported.

CBS News Article

One Dose of HPV Vaccine May Be Sufficient in Certain Situations

THURSDAY, Aug. 1, 2019 (HealthDay News) -- One dose of prophylactic human papillomavirus (HPV) vaccine may be as effective as two or three doses in preventing high-grade disease in a high-coverage setting, according to a study published online July 15 in Papillomavirus Research.

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Dietary Vitamin A Intake Tied to Reduced Risk for Squamous Cell Carcinoma

THURSDAY, Aug. 1, 2019 (HealthDay News) -- Increased dietary vitamin A seems to be associated with a reduced risk for incident cutaneous squamous cell carcinoma (SCC), according to a study published online July 31 in JAMA Dermatology.

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