February 2019 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for February 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Performance Improvement Sustained After DBT Adoption

THURSDAY, Feb. 28, 2019 (HealthDay News) -- Performance improvements after adoption of digital breast tomosynthesis (DBT) relative to digital mammography (DM) performance have been sustained, regardless of DBT volume, according to a study published online Feb. 26 in Radiology.

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Achievement of Targets in T2DM Varies by Season

WEDNESDAY, Feb. 27, 2019 (HealthDay News) -- There is seasonal variation in achievement of the guideline targets for hemoglobin A1c (HbA1c), blood pressure (BP), and low-density lipoprotein (LDL) cholesterol among persons with type 2 diabetes mellitus (T2DM), according to a study published online Feb. 22 in Diabetes Care.

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Adjuvant Tx for Early Testicular Cancer Does Not Harm Sperm

WEDNESDAY, Feb. 27, 2019 (HealthDay News) -- For clinical stage I testicular cancer (TC) patients, adjuvant treatment after orchiectomy has no long-term significant effect on sperm production, according to a study published online Feb. 25 in the Annals of Oncology.

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Decline Observed in HPV Type 16/18 Cervical Precancers in U.S.

WEDNESDAY, Feb. 27, 2019 (HealthDay News) -- The proportion of human papillomavirus (HPV) 16/18-positive cervical intraepithelial neoplasia grades 2 to 3 or adenocarcinoma in situ (CIN2+) declined from 2008 to 2014, according to a study published online Feb. 21 in Cancer Epidemiology, Biomarkers & Prevention.

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Single-Application FIT Moderately Sensitive, Specific for CRC

MONDAY, Feb. 25, 2019 (HealthDay News) -- Single-application fecal immunochemical tests (FITs) have moderate-to-high sensitivity and specificity for colorectal cancer (CRC), according to a review published online Feb. 26 in the Annals of Internal Medicine.

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2014 to 2017 Saw Improvement in Burnout for U.S. Physicians

MONDAY, Feb. 25, 2019 (HealthDay News) -- From 2014 to 2017, there was an improvement in burnout and satisfaction with work-life integration among U.S. physicians, according to a study published online Feb. 22 in the Mayo Clinic Proceedings.

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Incidence of Acute Myocardial Infarctions Up Among Young Women

MONDAY, Feb. 25, 2019 (HealthDay News) -- The incidence of acute myocardial infarctions (AMI) has increased among younger women, and sedentary time is associated with an increased risk for cardiovascular disease (CVD) among women, according to two studies published in the Feb. 19 issue of Circulation, a "Go Red for Women" theme issue on cardiovascular disease in women.

Abstract/Full Text - Arora
Editorial
Abstract/Full Text - Bellettiere

Genetic Variant Tied to Leukemia Risk in Hispanic Children

MONDAY, Feb. 25, 2019 (HealthDay News) -- Genetic variations have been identified in the ERG gene that are associated with an increased risk for acute lymphoblastic leukemia (ALL) in Hispanic children, according to a study recently published in Blood.

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National Health Spending Set to Increase 5.5 Percent Annually

FRIDAY, Feb. 22, 2019 (HealthDay News) -- National health spending is projected to increase at an annual rate of 5.5. percent from 2018 to 2027, with fundamental economic and demographic factors the main drivers, according to a report published online Feb. 20 in Health Affairs.

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Most Patients Do Not Disclose Complementary Medicine Use

FRIDAY, Feb. 22, 2019 (HealthDay News) -- Just one-third of users of biologically based complementary medicine (CM) disclose their use to traditional health care providers, according to a review published online Feb. 7 in Scientific Reports.

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44.4 Million Estimated to Be Diagnosed With Cervical Cancer by 2069

FRIDAY, Feb. 22, 2019 (HealthDay News) -- In the absence of further intervention, in the next 50 years, an estimated 44.4 million women will be diagnosed with cervical cancer globally, according to a study published online Feb. 19 in The Lancet Oncology.

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8 More U.S. Communities to Be Assessed for PFAS Toxin Exposure

THURSDAY, Feb. 21, 2019 (HealthDay News) -- Eight additional communities near current or former U.S. military installations that will be included in assessments of human exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) were announced Thursday by federal officials.

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U.S. Agencies Probing Johnson & Johnson Over Asbestos in Talc

THURSDAY, Feb. 21, 2019 (HealthDay News) -- Johnson & Johnson is being investigated by the U.S. Justice Department and the U.S. Securities and Exchange Commission over possible asbestos contamination of the company's baby powder and other talc-based products.

The New York Times Article
More Information - American Cancer Society

Vertical Integration Has Little Impact on Quality Measures

THURSDAY, Feb. 21, 2019 (HealthDay News) -- Vertical integration between hospitals and physicians has little impact on quality measures, while increased hospital market concentration is strongly associated with reduced quality in measures of patient satisfaction, according to a study published online Feb. 9 in Medical Care Research and Review.

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Experimental Test May Quickly Diagnose Sepsis

WEDNESDAY, Feb. 20, 2019 (HealthDay News) -- A blood test that can quickly diagnose dangerous sepsis infections has been developed, according to research published in the Feb. 1 issue of Biosensors and Bioelectronics.

CNN Article
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New Kaiser Permanente Medical School Plans to Waive Tuition

WEDNESDAY, Feb. 20, 2019 (HealthDay News) -- A new medical school to be opened by California-based health system Kaiser Permanente will waive tuition for all students in its first five graduating classes.

The New York Times Article
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Altered Gut Microbiome Seen in Patients With Active Lupus

WEDNESDAY, Feb. 20, 2019 (HealthDay News) -- The microbiome of patients with systemic lupus erythematosus (SLE), particularly those with increased disease activity, has reduced taxonomic complexity, according to a study published online Feb. 19 in the Annals of the Rheumatic Diseases.

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Glottic Carcinoma Can Be HPV-Related Disease in Young Adults

WEDNESDAY, Feb. 20, 2019 (HealthDay News) -- An increased incidence of glottic carcinoma related to human papillomavirus (HPV) has been documented in recent years among young patients, according to a study published online Jan. 27 in the Annals of Otology, Rhinology & Laryngology.

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USPSTF Says Screen Women With Higher Risk for BRCA Mutations

TUESDAY, Feb. 19, 2019 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends screening for women at increased risk for carrying a BRCA1/2 mutation as well as genetic counseling and testing as indicated for those screening positive. These recommendations form the basis of a draft recommendation statement published online Feb. 19 by the USPSTF.

Draft Evidence Review
Draft Recommendation Statement
Comment on Recommendation

Oncotype DX Not Cost-Effective for Low-Risk Breast Cancer

TUESDAY, Feb. 19, 2019 (HealthDay News) -- The multigene expression test Oncotype DX (ODX) is not cost-effective for women with breast cancer who are at low risk for recurrence, according to research published online Jan. 22 in the Journal of the National Comprehensive Cancer Network.

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Low Vitamin D Tied to High Blood Glucose Levels in Women

TUESDAY, Feb. 19, 2019 (HealthDay News) -- Lower serum 25-hydroxyvitamin D (25[OH]D) concentrations appear to be associated with high blood glucose levels in women, according to a study recently published online in Menopause.

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Hospital Prices Growing Faster Than Physician Prices

FRIDAY, Feb. 15, 2019 (HealthDay News) -- Growth in hospital prices and payments outpaced growth in physician prices and payments from 2007 through 2014, according to a report published in the February issue of Health Affairs.

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Artificial Intelligence Predicts Survival in Epithelial Ovarian Cancer

FRIDAY, Feb. 15, 2019 (HealthDay News) -- Artificial intelligence software can predict prognosis in epithelial ovarian cancer (EOC) above established prognostic methods, according to a study published online Feb. 15 in Nature Communications.

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Child Enterovirus Infection May Up Risk for Developing Celiac Disease

THURSDAY, Feb. 14, 2019 (HealthDay News) -- A higher frequency of enterovirus infections in early childhood is associated with an increased risk for developing celiac disease, according to a study published online Feb. 13 in the The BMJ.

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Editorial

p, p'-DDT Exposure Linked to Breast Cancer Through Age 54

THURSDAY, Feb. 14, 2019 (HealthDay News) -- p, p'-dichlorodiphenyltrichloroethane (DDT) is associated with breast cancer through age 54 years, according to a study published online Feb. 13 in the Journal of the National Cancer Institute.

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Autologous Stem Cell Transplant May Aid Some With Nodal PTCL

WEDNESDAY, Feb. 13, 2019 (HealthDay News) -- Autologous stem cell transplantation (ASCT) may be beneficial for some patients with nodal peripheral T-cell lymphoma (PTCL) in the first complete remission (CR1), according to a study published online Jan. 29 in Cancer.

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Midlife Systemic Inflammation Linked to Later Cognitive Decline

WEDNESDAY, Feb. 13, 2019 (HealthDay News) -- Midlife systemic inflammation is associated with cognitive decline, according to a study published online Feb. 14 in Neurology.

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Progress Made in Developing New Antibacterial Agents

WEDNESDAY, Feb. 13, 2019 (HealthDay News) -- Although there has been progress in the development of new antibacterial drugs, most of the recently approved agents have been modifications of existing chemical classes of antibiotics, according to research published online Feb. 1 in Clinical Infectious Diseases.

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Neoadjuvant PD-1 Blockade Seems Effective in Glioblastoma

WEDNESDAY, Feb. 13, 2019 (HealthDay News) -- Neoadjuvant administration of programmed cell death protein 1 (PD-1) blockade seems to enhance local and systemic antitumor immune response in glioblastoma, according to a study published online Feb. 11 in Nature Medicine.

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Health Care Spending Per Person Increased to $5,641 in 2017

TUESDAY, Feb. 12, 2019 (HealthDay News) -- In 2017, health care spending per person reached $5,641, according to the Health Care Cost Institute (HCCI) annual Health Care Cost and Utilization Report.

Health Care Cost and Utilization Report

Many Systematic Reviews Do Not Fully Report Adverse Events

TUESDAY, Feb. 12, 2019 (HealthDay News) -- Many systematic review protocols in the International Prospective Register of Systematic Reviews (PROSPERO) do not include adverse event reporting, according to a study published in the April issue of the Journal of Clinical Epidemiology.

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CDC: Screening Policies for Critical Congenital Heart Dz Widespread

TUESDAY, Feb. 12, 2019 (HealthDay News) -- All 50 states and the District of Columbia have implemented newborn screening policies for critical congenital heart disease (CCHD), although there are opportunities for improving data collection, according to research published in the Feb. 8 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Congo Ebola Outbreak Claims Nearly 100 Children's Lives

MONDAY, Feb. 11, 2019 (HealthDay News) -- The ongoing Ebola outbreak in the Democratic Republic of Congo has claimed the lives of nearly 100 children, and the number of cases are on the rise, according to the charity Save the Children.

CNN Article
More Information: CDC

Rates of Diabetes Screening High Among Adults Age ≥45

MONDAY, Feb. 11, 2019 (HealthDay News) -- Rates of diabetes screening are high, with hemoglobin A1c (HbA1c) used less but more likely to result in clinical diagnosis, according to a study published online Feb. 6 in Diabetes Care.

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Smaller Germinal Centers Identified in Recurrent Tonsillitis

MONDAY, Feb. 11, 2019 (HealthDay News) -- Children with recurrent tonsillitis (RT) have smaller germinal centers, according to a study published in the Feb. 6 issue of Science Translational Medicine.

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Education Not Tied to Rate of Cognitive Change in Seniors

FRIDAY, Feb. 8, 2019 (HealthDay News) -- Education is associated with global cognition but not with the rate of cognitive change in older adults, according to a study published online Feb. 6 in Neurology.

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High-Risk HPV Infection Linked to Increased Risk for CVD in Women

FRIDAY, Feb. 8, 2019 (HealthDay News) -- High-risk human papillomavirus (HPV) infection is associated with an increased risk for developing cardiovascular disease (CVD), according to a study published online Feb. 7 in Circulation Research.

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FDA: Number of U.S. Women With Breast Implant-Caused Cancer Has Increased

THURSDAY, Feb. 7, 2019 (HealthDay News) -- There has been an increase in the number of U.S. women diagnosed with a cancer caused by breast implants, the U.S. Food and Drug Administration said Wednesday.

NBC News Article
More Information: FDA
Letter to Health Care Providers

Discord Found in Clinician-, Criteria-Based Fibromyalgia Diagnosis

THURSDAY, Feb. 7, 2019 (HealthDay News) -- There is disagreement between clinical diagnosis and criteria-based diagnosis of fibromyalgia, according to a study published online Feb. 6 in Arthritis Care & Research.

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Patient Tested for Ebola at Philadelphia Hospital

WEDNESDAY, Feb. 6, 2019 (HealthDay News) -- Preliminary results from a patient being tested for Ebola suggest that the patient has another condition, say officials at the Hospital of the University of Pennsylvania in Philadelphia.

NBC News Article

USPSTF Still Recommends Against Pancreatic Cancer Screening

TUESDAY, Feb. 5, 2019 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends against screening for pancreatic cancer in asymptomatic adults. These findings form the basis of a draft recommendation statement published online Feb. 5 by the USPSTF.

Draft Recommendation Statement
Draft Evidence Review
Comment on Recommendation Statement

Early Tau Deposition Elevated for Women Versus Men

MONDAY, Feb. 4, 2019 (HealthDay News) -- For older adults on the Alzheimer disease trajectory, women have elevated early tau deposition compared with men, according to a study published online Feb. 4 in JAMA Neurology.

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Expanded Recall of Warfarin Level Monitoring Test Strips

MONDAY, Feb. 4, 2019 (HealthDay News) -- Certain lots of Roche Diagnostics test strips should not be used with CoaguChek test meter devices to check levels of the blood thinner warfarin because patients may get inaccurate results and be at risk for serious injury or death, the U.S. Food and Drug Administration says in an updated recall notice.

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Sponge Cytology-Sampling Device Promising for Barrett Esophagus Dx

MONDAY, Feb. 4, 2019 (HealthDay News) -- A swallowable cellular retrieval capsule sponge cytology-sampling device, EsophaCap, in combination with a methylation biomarker panel represents a promising strategy for diagnosing Barrett esophagus (BE), according to a study published online Jan. 22 in Clinical Cancer Research.

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Some Obesity-Related Cancers Increasing in Younger Adults

MONDAY, Feb. 4, 2019 (HealthDay News) -- The incidence of some obesity-related cancers is increasing in younger generations, according to a study published online Feb. 3 in The Lancet Public Health.

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Editorial

Longitudinal TNF Levels Mainly Stable With Adalimumab in RA

FRIDAY, Feb. 1, 2019 (HealthDay News) -- For patients with rheumatoid arthritis (RA), longitudinal tumor necrosis factor (TNF) concentrations are mainly stable during adalimumab treatment, although early low TNF is strongly linked to nonresponse to treatment, according to a study published in the Jan. 30 issue of Science Translational Medicine.

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Use of Image Analysis to ID HER2 Status in Breast Cancer Outlined

FRIDAY, Feb. 1, 2019 (HealthDay News) -- Recommendations have been developed to improve accuracy, precision, and reproducibility in the interpretation of human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) results for breast cancer with use of quantitative image analysis (QIA); the guideline was published online Jan. 15 in the Archives of Pathology & Laboratory Medicine.

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Maternal Glucose in Pregnancy Tied to Child's Glucose Outcomes

FRIDAY, Feb. 1, 2019 (HealthDay News) -- In utero exposure to higher levels of maternal glucose is associated with higher glucose levels and insulin resistance during childhood, according to a study published online Jan. 7 in Diabetes Care.

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