March 2019 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for March 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Simple Rapid Urine Test Can Help Diagnose Preeclampsia

FRIDAY, March 29, 2019 (HealthDay News) -- A simple point-of-care urine test can rapidly detect preeclampsia, according to a study published in the February issue of EClinicalMedicine.

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Recommendations Presented on Genetic Testing in Psychiatry

FRIDAY, March 29, 2019 (HealthDay News) -- Recommendations have been developed for the use of genetic testing in psychiatric care, according to a statement published by the International Society of Psychiatric Genetics (ISPG).

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Starting Colorectal Cancer Screening at Age 45 Years Is Cost-Effective

FRIDAY, March 29, 2019 (HealthDay News) -- Starting colorectal cancer (CRC) screening at age 45 instead of 50 years seems cost-effective, but greater benefits could be achieved by increasing participation rates for unscreened older individuals, according to a study published online March 28 in Gastroenterology.

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CDC: 2017 to 2018 Saw Increase in Enterovirus D68 Detection

FRIDAY, March 29, 2019 (HealthDay News) -- Based on active surveillance data of acute respiratory illness (ARI), enterovirus D68 (EV-D68) was detected in 0.8 percent of patients in 2017 and in 13.9 percent in 2018, according to research published in the March 29 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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California Man Awarded $80 Million in Roundup Lawsuit

THURSDAY, March 28, 2018 (HealthDay News) -- A California man who said that Monsanto's weedkiller Roundup caused his cancer was awarded $80 million in damages by a jury in San Francisco on Wednesday.

AP News Article

Guidance Lists New First-Line Treatment for Severe Malaria in the U.S.

THURSDAY, March 28, 2019 (HealthDay News) -- The drug artesunate -- the World Health Organization-recommended first-line treatment for severe malaria -- will become the first-line treatment for severe malaria in the United States, the U.S. Centers for Disease Control and Prevention says in a new guidance to health care providers.

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Tooth Loss May Up Pancreatic Cancer Risk in Black Women

THURSDAY, March 28, 2019 (HealthDay News) -- Tooth loss is associated with an increased risk for incident pancreatic cancer in African-American women, according to a study published online March 28 in Cancer Epidemiology, Biomarkers & Prevention.

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Doctors With Malpractice Claims More Likely to Leave Medicine

THURSDAY, March 28, 2019 (HealthDay News) -- Physicians with one or more paid malpractice claims are more likely to leave practice or shift into smaller practice settings, according to a study published in the March 28 issue of the New England Journal of Medicine.

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Douglas County, Colorado, Ranked as Healthiest Community

TUESDAY, March 26, 2019 (HealthDay News) -- The 2019 healthiest community in America is Douglas County, Colorado, according to a report published online March 26 by U.S. News & World Report, in conjunction with the Aetna Foundation.

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Smoking Seems Not to Be Linked to Increased Dementia Risk

TUESDAY, March 26, 2019 (HealthDay News) -- After adjusting for the competing risk of death without dementia, smoking is not associated with an increased risk for dementia, according to a study published online March 26 in the Journal of Alzheimer's Disease.

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Radiomic Features May Predict Response to Chemo in NSCLC

TUESDAY, March 26, 2019 (HealthDay News) -- For patients with lung adenocarcinoma, radiomic texture features extracted from within and around the nodule on baseline computed tomography (CT) scans can predict response to chemotherapy, according to a study published online March 20 in Radiology: Artificial Intelligence.

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Avocados Recalled by California Company

MONDAY, March 25, 2019 (HealthDay News) -- Possible listeria contamination has led to a recall of avocados by Henry Avocado, a grower and distributor based near San Diego.

AP News Article
More Information: FDA

2019 Residency Match Day Was Largest in History

MONDAY, March 25, 2019 (HealthDay News) -- The 2019 Main Residency Match was the largest in history, with a record high of 38,376 applicants for 35,185 positions, according to 2019 Match Day results released by the National Resident Matching Program.

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Ocular Protein Levels May Be Useful for Alzheimer Testing

MONDAY, March 25, 2019 (HealthDay News) -- Patients with poor cognitive function have significantly lower levels of Alzheimer disease-related biomarkers in the vitreous humor, according to a study published March 8 in the Journal of Alzheimer's Disease.

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Prenatal Pesticide Exposure Linked to Increased Risk for Autism

FRIDAY, March 22, 2019 (HealthDay News) -- Prenatal exposure to ambient pesticides within 2,000 m of maternal residence during pregnancy is associated with an increased risk for autism spectrum disorder, according to a study published online March 20 in The BMJ.

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More Vascular Risk Factors Tied to Worse Brain Health

FRIDAY, March 22, 2019 (HealthDay News) -- A higher number of vascular risk factors (VRFs) is associated with poorer brain health across gray and white matter macrostructure and microstructure, according to a study published online March 11 in the European Heart Journal.

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Digital Breast Tomosynthesis Can Reduce Benign Biopsy Rate

THURSDAY, March 21, 2019 (HealthDay News) -- Digital breast tomosynthesis (DBT) can reduce the rate of benign biopsies without affecting cancer detection compared with full-field digital mammography (FFDM), according to a study published online March 19 in Radiology.

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Prevalence of Severe Maternal Morbidity Increased Across Groups

THURSDAY, March 21, 2019 (HealthDay News) -- From 1997 to 2014, there was an increase in the prevalence of severe maternal morbidity (SMM), with persistent racial/ethnic disparities, according to a study published online Feb. 28 in the Annals of Epidemiology.

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Jury Finds Roundup a Major Contributor to Man's Cancer

WEDNESDAY, March 20, 2018 (HealthDay News) -- Monsanto's Roundup weedkiller was a major factor in a California man's cancer, a federal jury in San Francisco has ruled.

The Guardian Article

Recommendations Issued for HSCT in Multiple Myeloma

WEDNESDAY, March 20, 2019 (HealthDay News) -- A consensus statement for the use of hematopoietic stem cell transplantation (HSCT) in the treatment of multiple myeloma (MM) has been developed by Mayo Clinic physicians; the recommendations were published in the March issue of Bone Marrow Transplantation.

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Breast Density Categorization Varies With Screening Modality

WEDNESDAY, March 20, 2019 (HealthDay News) -- Breast Imaging Reporting and Data System (BI-RADS) breast density categorization may vary by screening mammographic modality, according to a study published online March 19 in Radiology.

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Overall, Physicians Are Happy and Enjoy Their Lives

WEDNESDAY, March 20, 2019 (HealthDay News) -- Overall, physicians are happy and enjoy their lives, according to the 2019 American Academy of Family Physicians (AAFP)/CompHealth Physician Happiness Survey published online March 19.

2019 AAFP/CompHealth Physician Happiness Survey

Favorable Outcomes Seen in Long Term for ALLR3 Trial

TUESDAY, March 19, 2019 (HealthDay News) -- For children with B-cell precursor acute lymphoblastic leukemia with late bone marrow relapse, risk stratification by minimal residual disease seems to be an effective strategy for treatment, according to a study recently published in The Lancet Haematology.

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In Utero Ultrafine Particle Exposure Tied to Asthma in Offspring

MONDAY, March 18, 2019 (HealthDay News) -- Exposure to ultrafine particles (UFPs; <0.1 μm) during the second trimester in utero is linked to the subsequent onset of asthma in children, according to a study published online Feb. 20 in the American Journal of Respiratory and Critical Care Medicine.

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Adenocarcinoma, High-Grade Dysplasia Up With Barrett Esophagus

MONDAY, March 18, 2019 (HealthDay News) -- The prevalence of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) has significantly increased since 1995 in patients with Barrett esophagus (BE), according to a study published in the February issue of Gastrointestinal Endoscopy.

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Reported Cases of Spotted Fever Rickettsioses Rarely Confirmed

MONDAY, March 18, 2019 (HealthDay News) -- Only 1.0 percent of reported cases of spotted fever rickettsioses (SFR) meet the confirmed case definition, according to research published in the March 15 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Cancer Risk Modestly Elevated With Chronic Kidney Disease

MONDAY, March 18, 2019 (HealthDay News) -- Individuals with chronic kidney disease (CKD) have a modestly elevated cancer risk, according to a study published online March 14 in the Clinical Journal of the American Society of Nephrology.

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Average of 8.8 Inactive Ingredients Found in Oral Medications

MONDAY, March 18, 2019 (HealthDay News) -- Oral forms of medications contain an average of 8.8 inactive ingredients, many of which could cause adverse reactions, according to a perspective piece published in the March 13 issue of Science Translational Medicine.

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Physician Burnout Rate Increased From 2014 to 2017

FRIDAY, March 15, 2019 (HealthDay News) -- From 2014 to 2017, there was an increase in physician burnout, with early-career physicians being the most susceptible, according to a study published online March 15 in JAMA Network Open.

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ASCO: Guidelines Released for Early Detection, Treatment of CRC

FRIDAY, March 15, 2019 (HealthDay News) -- Expert guidance has been provided on the early detection of colorectal cancer and on treatment and posttreatment follow-up; the two guidelines were recently published online in the Journal of Global Oncology.

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Risk Profiles ID'd for Patients With Transplant Glomerulopathy

FRIDAY, March 15, 2019 (HealthDay News) -- An archetypal approach can identify the diagnostic and prognostic features associated with transplant glomerulopathy, according to a study published online March 14 in the Journal of the American Society of Nephrology.

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Troponin Assay Confusion May Cause Misdiagnosis of Acute MI

THURSDAY, March 14, 2019 (HealthDay News) -- The 99th centile of high-sensitivity cardiac troponin I (hs-cTnI) concentration is substantially higher in a hospital population than the manufacturer's recommended upper limit of normal (ULN), according to a study published online March 13 in The BMJ.

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New AI Model May Predict Cancerous Lung Nodules

THURSDAY, March 14, 2019 (HealthDay News) -- The Lung Cancer Causal Model (LCCM) shows promise as a predictor of cancerous lung nodules, according to a study published online March 12 in Thorax.

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Having Affected Relatives Linked to Increased Alzheimer Risk

THURSDAY, March 14, 2019 (HealthDay News) -- Having affected first-degree, second-degree, or third-degree relatives (FDRs, SDRs, and TDRs) is associated with an increased risk for Alzheimer disease (AD), according to a study published online March 13 in Neurology.

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'Brain Vital Signs' Detect Concussion-Related Changes

THURSDAY, March 14, 2019 (HealthDay News) -- Brainwave monitoring can detect concussion-related brain changes as well as subclinical impairment in hockey players, according to a study recently published in Brain.

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Head of National Cancer Institute Named Acting FDA Commissioner

WEDNESDAY, March 13, 2019 (HealthDay News) -- The U.S. Food and Drug Administration will temporarily be overseen by the head of the National Cancer Institute when FDA Commissioner Scott Gottlieb, M.D., leaves the post next month.

AP News Article

Adding Bempedoic Acid to Statin Therapy Reduces LDL Cholesterol

WEDNESDAY, March 13, 2019 (HealthDay News) -- Bempedoic acid, an inhibitor of ATP citrate lyase (ACLY), added to maximally tolerated statin therapy, significantly reduces levels of low-density lipoprotein (LDL) cholesterol in patients with atherosclerotic cardiovascular disease and/or heterozygous familial hypercholesterolemia, according to a study published in the March 14 issue of the New England Journal of Medicine.

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CDC: Most Americans Report Excellent, Good Health

WEDNESDAY, March 13, 2019 (HealthDay News) -- Most Americans report having excellent or good health and have a usual place to go for medical care, according to a report published March 13 for the National Health Interview Survey Early Release Program.

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Noncontrast Brain MRI Effective for Monitoring Multiple Sclerosis

WEDNESDAY, March 13, 2019 (HealthDay News) -- For patients with multiple sclerosis (MS), use of a contrast-based agent at follow-up magnetic resonance imaging (MRI) does not change the diagnosis of interval disease progression, according to a study published online March 12 in Radiology.

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Active Bathing in Non-ICU Setting Does Not Cut Infections

WEDNESDAY, March 13, 2019 (HealthDay News) -- Daily bathing with chlorhexidine plus nasal mupirocin in carriers for methicillin-resistant Staphylococcus aureus (MRSA) does not cut rates of hospital-acquired bacterial infections overall in non-critical care units, but benefit is observed in patients with medical devices, according to a study published online March 5 in The Lancet.

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Editorial (subscription or payment may be required)

Parity, Risk for Breast Cancer Studied for BRCA1/2 Carriers

WEDNESDAY, March 13, 2019 (HealthDay News) -- The correlation between reproductive events and breast cancer risk varies for BRCA1 and BRCA2 mutation carriers, according to a study published March 8 in JNCI Cancer Spectrum.

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Model Can Predict Survival in Nonmetastatic Prostate Cancer

TUESDAY, March 12, 2019 (HealthDay News) -- An individualized, multivariable model can predict survival in patients with nonmetastatic prostate cancer (PCa), according to a study published online March 12 in PLOS Medicine.

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Total Thyroidectomy Improves HRQoL in Hashimoto Thyroiditis

TUESDAY, March 12, 2019 (HealthDay News) -- For patients with Hashimoto thyroiditis with persistent symptoms despite normal thyroid gland function, total thyroidectomy, but not medical management, improves health-related quality of life and fatigue, according to a study published online March 12 in the Annals of Internal Medicine.

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Retinal Microvascular Changes Identified in Alzheimer Disease

MONDAY, March 11, 2019 (HealthDay News) -- Individuals with Alzheimer disease (AD) have changes in the retinal microvasculature in the superficial capillary plexus (SCP) compared with those with mild cognitive impairment (MCI) and controls, according to a study published online March 11 in Ophthalmology Retina.

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Distinct Etiology Found for Colorectal Cancer With Early Onset

MONDAY, March 11, 2019 (HealthDay News) -- Onset of colorectal cancer (CRC) in adults younger than 50 years is distinct from onset in patients aged 50 years or older, according to a study published online March 11 in Cancer.

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Patterns of Joint Behavior Useful for Juvenile Arthritis Classification

MONDAY, March 11, 2019 (HealthDay News) -- An algorithm that can classify patients with juvenile idiopathic arthritis (JIA) into seven distinct groups based on patterns of swollen or painful joints in the body can help predict disease course, according to a study published online Feb. 26 in PLOS Medicine.

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Genetic Testing Recommended for All Patients With Breast Cancer

FRIDAY, March 8, 2019 (HealthDay News) -- Genetic testing should be made available to all patients with a history of breast cancer, according to an updated consensus guideline from the American Society of Breast Surgeons (ASBS).

Consensus Guideline on Genetic Testing for Hereditary Breast Cancer

Probiotic Sanitation Cuts Antimicrobial Resistance in Hospitals

THURSDAY, March 7, 2019 (HealthDay News) -- An environmental intervention of probiotic sanitation can effectively alter hospital microbiota, helping to limit the spread of antimicrobial resistance (AMR) in health care-associated infections (HAIs), according to a study published online Feb. 27 in Infection and Drug Resistance.

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Conversion From Sleep Disorder to Neurodegeneration Studied

THURSDAY, March 7, 2019 (HealthDay News) -- Predictors of neurodegeneration from idiopathic REM sleep behavior disorder (iRBD) have been identified, according to a study published online Feb. 20 in Brain.

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Endogenous Testosterone Linked to Cardiovascular Disease

THURSDAY, March 7, 2019 (HealthDay News) -- In men, endogenous testosterone may have a causal role in thromboembolism, heart failure, and myocardial infarction, according to a study published online March 6 in The BMJ.

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Hospital-Onset MRSA Decreased From 2002 to 2015

WEDNESDAY, March 6, 2019 (HealthDay News) -- Staphylococcus aureus infections are still a concern in the United States, despite a decline seen in hospital-onset methicillin-resistant S. aureus (MRSA) infections since 2005, according to two reports published in the March 5 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Blood Test Offers Early Warning for Kidney Transplant Rejection

WEDNESDAY, March 6, 2019 (HealthDay News) -- A gene expression signature can identify T-cell mediated rejection (TCMR) ahead of time in kidney transplant recipients, according to a study published online March 1 in EBioMedicine.

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FDA Commissioner Dr. Scott Gottlieb Resigns

TUESDAY, March 5, 2019 (HealthDay News) -- In what probably came as a surprise to many, U.S. Food and Drug Administration Commissioner Scott Gottlieb, M.D., announced his resignation on Tuesday. Gottlieb is leaving the FDA because he wants to spend more time with his wife and three young daughters -- twins aged 9 and a 5-year-old -- one official said. He currently commutes each week from the family home in Connecticut to his Washington, D.C., office.

The Washington Post Article

Second Man HIV-Free After Stem Cell Transplant

TUESDAY, March 5, 2019 (HealthDay News) -- In only the second known case worldwide, a man is free of HIV after a stem cell transplant, doctors say.

AP News Article
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Methanol Toxicity Can Result From Occupational Exposure

TUESDAY, March 5, 2019 (HealthDay News) -- Methanol toxicity can occur as a consequence of occupational exposure, according to a research letter published online March 5 in the Annals of Internal Medicine.

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Recommendations Developed for Ulcerative Colitis Management

TUESDAY, March 5, 2019 (HealthDay News) -- Recommendations have been developed for management of adults with ulcerative colitis (UC); the American College of Gastroenterology clinical guideline was published online Feb. 21 in the American Journal of Gastroenterology.

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