September 2018 Briefing - Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for September 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Physicians Often Don't Address Their Burnout

FRIDAY, Sept. 28, 2018 (HealthDay News) -- More than half of physicians experience burnout, and many do not seek treatment for burnout, according to a report published in the American Medical Association's AMA Wire.

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Handheld Device Inspired by Star Trek May Allow Rapid Diagnosis

FRIDAY, Sept. 28, 2018 (HealthDay News) -- A device inspired by the Star Trek famous tricorder device pairs a handheld sensor with a smartphone app to measure the levels of various metabolites associated with multiple diseases in fluid samples from patients, according to a report published in an upcoming issue of Biosensors and Bioelectronics.

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Business Degree Increasingly Useful for Doctors

THURSDAY, Sept. 27, 2018 (HealthDay News) -- Having a Master of Business Administration degree (M.B.A.) can help doctors with important, practice-related decisions, according to a report published recently in Physician Practice.

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Heading a Soccer Ball Found to Be Riskier for Female Players

THURSDAY, Sept. 27, 2018 (HealthDay News) -- Female soccer players exhibit more widespread evidence of microstructural white matter alteration than males, despite having similar exposure to heading, according to a study recently published in Radiology.

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Machine Learning Can Improve Chemical Toxicity Prediction

THURSDAY, Sept. 27, 2018 (HealthDay News) -- Machine learning of toxological big data can predict the toxicity of chemicals, and may be more reliable than animal testing, according to a study published in the September issue of Toxicological Sciences.

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Single Agent Treats Two Cancers With Same Genetic Cause

THURSDAY, Sept. 27, 2018 (HealthDay News) -- A single checkpoint inhibitor can be used to successfully treat two simultaneous types of primary cancer in a patient with Lynch syndrome, according to a research letter published online Sept. 25 in the Annals of Internal Medicine.

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Practices Should Set Rules for Staff Social Media Use

THURSDAY, Sept. 27, 2018 (HealthDay News) -- Medical practices can take steps to avoid problems related to use of social media by staff members, according to an article published in Medical Economics.

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Burnout, Career Choice Regret Prevalent in U.S. Residents

WEDNESDAY, Sept. 26, 2018 (HealthDay News) -- Symptoms of burnout and career choice regret are prevalent among U.S. resident physicians, according to a study published in the Sept. 18 issue of the Journal of the American Medical Association.

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Lack of CHD4 Leads to Abnormal Myofibrils, Heart Defects

TUESDAY, Sept. 25, 2018 (HealthDay News) -- The absence of CHD4 in heart cells results in inappropriate production of non-cardiac muscle proteins, which subsequently leads to heart defects, according to an animal study published recently in the Proceedings of the National Academy of Sciences.

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Cancer-Related Gene Variations Frequently Reclassified

TUESDAY, Sept. 25, 2018 (HealthDay News) -- Among individuals undergoing hereditary cancer testing, some variants of uncertain significance are reclassified, with almost one-quarter of those variants reclassified at a single commercial laboratory, according to a study published in the Sept. 25 issue of the Journal of the American Medical Association.

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In 2016, Proportion of Uninsured Americans Down to 10 Percent

TUESDAY, Sept. 25, 2018 (HealthDay News) -- From 2013 to 2016 there was a reduction in uninsurance among Americans from 17 to 10 percent, according to a report published in September by the Robert Wood Johnson Foundation (RWJF) and the Urban Institute.

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Physician-Group ACOs Generate Medicare Savings

TUESDAY, Sept. 25, 2018 (HealthDay News) -- Physician-group accountable care organizations (ACOs) participating in the Medicare Shared Savings Program (MSSP) generated significantly more savings for Medicare that grew from 2012 to 2015 compared with hospital-integrated ACOs, according to research published in the Sept. 20 issue of the New England Journal of Medicine.

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New Risk Factors Identified for Varicose Vein Disease

MONDAY, Sept. 24, 2018 (HealthDay News) -- New risk factors have been identified for varicose vein disease, including height, according to a study published online Sept. 24 in Circulation.

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Multiple Pathways Explain Age-Linked Increase in Dementia Risk

MONDAY, Sept. 24, 2018 (HealthDay News) -- Multiple pathways account for the age-related increases in dementia risk, according to a study recently published in the Annals of Neurology.

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Brain Iron on MRI Linked to Disability in Multiple Sclerosis

MONDAY, Sept. 24, 2018 (HealthDay News) -- Brain iron at quantitative magnetic resonance imaging (MRI) is associated with disability in multiple sclerosis (MS), according to a study recently published in Radiology.

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Sensitivity for CRC Detection Up With Decreasing FIT Threshold

FRIDAY, Sept. 21, 2018 (HealthDay News) -- Programmatic sensitivity for colorectal cancer (CRC) detection increases modestly with decreasing fecal immunochemical test (FIT) positivity thresholds, according to a study published online Sept. 18 in the Annals of Internal Medicine.

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Age, Sex, APOE Genotype Identify Alzheimer's, Dementia Risk

FRIDAY, Sept. 21, 2018 (HealthDay News) -- Age, sex and apolipoprotein E (APOE) genotype can identify groups at high 10-year risk for Alzheimer's disease and all dementia, according to a study published Sept. 4 in CMAJ, the journal of the Canadian Medical Association.

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Promising New Way to Identify Breast Cancer Tumors

FRIDAY, Sept. 21, 2018 (HealthDay News) -- Molecular markers of breast cancer tumors can be identified by focusing on parameters of a cell's nucleus, and aided by machine learning, according to a study published online Sept. 4 in npj Breast Cancer.

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Dozens of Medical Groups Join Forces to Improve Diagnoses

FRIDAY, Sept. 21, 2018 (HealthDay News) -- Every nine minutes, a patient in a U.S. hospital dies because a diagnosis was wrong or delayed -- resulting in 80,000 deaths a year. That sobering estimate comes from the Society to Improve Diagnosis in Medicine (SIDM).

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Research Links Doctor Burnout to Patient Safety Incidents

THURSDAY, Sept. 20, 2018 (HealthDay News) -- Physician burnout is associated with increased risk of patient safety incidents, poorer quality of care due to low professionalism, and reduced patient satisfaction, according to a review published online Sept. 4 in JAMA Internal Medicine.

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Residents Should Take Advantage of Paid Time Off

THURSDAY, Sept. 20, 2018 (HealthDay News) -- Although there are many demands on residents, taking advantage of paid vacation time is one of the perks and should be maximized, according to an article published in the American Medical Association's AMA Wire.

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Patient Health Information Often Shared Electronically

WEDNESDAY, Sept. 19, 2018 (HealthDay News) -- The most common electronically sent and received types of patient health information (PHI) include laboratory results and medication lists, according to a report published Aug. 15 by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Opioid Deaths 1999 to 2015 May Be Dramatically Underestimated

WEDNESDAY, Sept. 19, 2018 (HealthDay News) -- States may be greatly underestimating the effect of opioid-related overdose deaths because of incomplete cause-of-death reporting, according to a study recently published in Public Health Reports.

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Second HPV-Related Primary Cancers Common in Survivors

WEDNESDAY, Sept. 19, 2018 (HealthDay News) -- The risk of human papillomavirus-associated second primary cancers (HPV-SPCs) among survivors of HPV-associated cancers is significant, according to a study published online Sept. 7 in JAMA Network Open.

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Global Prevalence of Insufficient Activity 27.5 Percent

WEDNESDAY, Sept. 19, 2018 (HealthDay News) -- In 2016 the age-standardized prevalence of insufficient physical activity was 27.5 percent, according to a study published in the October issue of The Lancet Global Health.

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Review: Treatments for Primary Basal Cell Carcinoma Compared

TUESDAY, Sept. 18, 2018 (HealthDay News) -- For patients with primary basal cell carcinoma (BCC), estimated recurrence rates are similarly low for excision, Mohs surgery, curettage and diathermy, and external-beam radiation, according to a review and meta-analysis published online Sept. 18 in the Annals of Internal Medicine.

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Incident Contrast Sensitivity Common in Middle-Aged Adults

TUESDAY, Sept. 18, 2018 (HealthDay News) -- The risk of incident contrast sensitivity (CS) impairment is increased with factors such as cadmium exposure and older age, according to a study published online Sept. 13 in JAMA Ophthalmology.

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Scribes Improve Physician Workflow, Patient Interaction

TUESDAY, Sept. 18, 2018 (HealthDay News) -- Use of medical scribes is associated with decreased physician documentation burden, improved work efficiency, and improved patient interactions, according to a study published online Sept. 17 in JAMA Internal Medicine.

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Compliance With Requirement to Report Results on EUCTR Is Poor

TUESDAY, Sept. 18, 2018 (HealthDay News) -- Half of trials on the European Union Clinical Trials Register (EUCTR) are non-compliant with the European Commission's requirement that all trials post results to the registry within 12 month of completion, according to a study published online Sept. 13 in The BMJ.

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Drug Prices Increase More Than Expected After Shortages

TUESDAY, Sept. 18, 2018 (HealthDay News) -- Prices for drugs under shortage increase more than twice as quickly as expected in the absence of a shortage, according to a research letter published online Sept. 18 in the Annals of Internal Medicine.

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Many RA Patients' Pain Related to Central Nervous System

MONDAY, Sept. 17, 2018 (HealthDay News) -- Centralized pain pathways may coexist with more established peripheral inflammation-driven pathways in some patients with rheumatoid arthritis (RA), according to a study published in the July issue of Arthritis & Rheumatology.

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Mercury in Traditional Tibetan Medicine Could Be Harmful

MONDAY, Sept. 17, 2018 (HealthDay News) -- The high mercury (Hg) concentration contained in traditional Tibetan medicine (TTM) could be harmful to humans and contribute to the environmental Hg burden in Tibet, according to a study published in the Aug. 7 issue of Environmental Science & Technology.

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Association Health Plans Can Help Small Businesses Offer Coverage

MONDAY, Sept. 17, 2018 (HealthDay News) -- Association health plans (AHPs) will provide small businesses with more choices, access, and coverage options, although critics warn that they may undermine the Affordable Care Act (ACA) marketplace, according to an article published in Managed Healthcare Executive.

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Situation Framing, Language Can Influence Decision-Making

FRIDAY, Sept. 14, 2018 (HealthDay News) -- How a situation is framed and the language used to describe risks can influence patients' decision-making, according to an article published in Physicians Practice.

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Extreme Flooding Can Up Exposure to Pathogens

FRIDAY, Sept. 14, 2018 (HealthDay News) -- Extreme flooding, such as was seen in Hurricane Harvey, can increase exposure to pathogens, according to a research letter published recently in Environmental Science & Technology.

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Experts Advise Against Universal DNA Sequencing of Newborns

THURSDAY, Sept. 13, 2018 (HealthDay News) -- Newborns should not undergo universal sequencing at birth, according to a report published in the July/August issue of The Hasting Center Report.

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Worse Health Status With Shorter Telomere Length in COPD

THURSDAY, Sept. 13, 2018 (HealthDay News) -- Patients with chronic obstructive pulmonary disease (COPD) with shorter telomere length have worse health status, according to a study published in the August issue of CHEST.

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Risks Posed by Spreading Oil and Gas Wastewater on Roads

THURSDAY, Sept. 13, 2018 (HealthDay News) -- Spreading oil and gas (O&G) wastewaters on roads may pose human and environmental risks, according to a study recently published in Environmental Science & Technology.

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Gains in Insurance Coverage Seen for Lesbian, Gay, Bisexual Adults

THURSDAY, Sept. 13, 2018 (HealthDay News) -- Lesbian, gay, and bisexual (LGB) adults report continued problems affording care despite coverage gains offered by the Affordable Care Act, according to a study published in the August issue of Health Affairs.

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At Least 15 Men Near Ground Zero Have Breast Cancer

WEDNESDAY, Sept. 12, 2018 (HealthDay News) -- At least 15 men who worked near Ground Zero after the 9/11 attacks have been diagnosed with breast cancer, a New York City law firm claims.

CBS News Article

High-Touch Surfaces at Airports Often Covered in Pathogens

WEDNESDAY, Sept. 12, 2018 (HealthDay News) -- Many frequently touched surfaces at airports are contaminated with respiratory virus pathogens, according to a study published online Aug. 29 in BMC Infectious Diseases.

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Better Classification of Dry Eye Disease Will Aid Diagnosis, Tx

WEDNESDAY, Sept. 12, 2018 (HealthDay News) -- Attention to the subtypes of dry eye disease may better equip clinicians to diagnose and treat cases, according to a review article recently published in the New England Journal of Medicine.

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Six-Step Analysis Can Help Improve Practice Logistics

WEDNESDAY, Sept. 12, 2018 (HealthDay News) -- A six-step analysis can help redesign and improve the outpatient health care process, according to a study recently published in the Journal of Evaluation in Clinical Practice.

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Residents Working Long Hours Can Increase Alertness

WEDNESDAY, Sept. 12, 2018 (HealthDay News) -- Medical residents can take steps to maintain their energy and alertness during long shifts, according to an article published in the American Medical Association's AMA Wire.

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Chest Radiograph Effective for Excluding Pediatric Pneumonia

TUESDAY, Sept. 11, 2018 (HealthDay News) -- A negative chest radiograph (CXR) accurately excludes pneumonia in the majority of children, according to a study published in the September issue of Pediatrics.

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Medicaid Work Requirements Don't Impact Many Enrollees

TUESDAY, Sept. 11, 2018 (HealthDay News) -- Medicaid work requirements will only impact a small proportion of persons and may only generate minimal savings, according to two research letters published online Sept. 10 in JAMA Internal Medicine.

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Total of 43,371 New Cases of HPV-Associated Cancers in 2015

TUESDAY, Sept. 11, 2018 (HealthDay News) -- A total of 43,371 new cases of human papillomavirus (HPV)-associated cancers were reported in 2015, with oropharyngeal squamous cell carcinoma (SCC) being the most common HPV-associated cancer, according to research published in the Aug. 24 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Data Age in Clinical Trials Is About Three Years at Publication

TUESDAY, Sept. 11, 2018 (HealthDay News) -- The median data age in clinical trials in journals with a high impact factor is about three years at publication, according to a study published in the Aug. 10 issue of JAMA Network Open.

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Many Opportunities for Doctors Using Twitter

MONDAY, Sept. 10, 2018 (HealthDay News) -- Doctors can use Twitter to build networks and learn more about research in real time, according to a blog post published by Penn Medicine News.

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Physician Burnout Rates Vary by Medical Specialty

MONDAY, Sept. 10, 2018 (HealthDay News) -- Nearly half of physicians report being burned out, but rates vary substantially by medical specialty, according to an article published in AMA Wire.

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Docs, Consumers Agree on Benefits of Virtual Care

MONDAY, Sept. 10, 2018 (HealthDay News) -- Physicians and consumers agree on the benefits of virtual care, but physician adoption of virtual care technologies is low, according to a report on the Deloitte 2018 Survey of U.S. Physicians.

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Exposure to Toxic Metals May Up Cardiovascular Disease Risk

FRIDAY, Sept. 7, 2018 (HealthDay News) -- Exposure to arsenic, lead, cadmium, and copper is associated with elevated risk of clinical cardiovascular disease outcomes, according to a review and meta-analysis published online Aug. 29 in The BMJ.

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Bigger Cut in Smoke Exposure for Immediate Nicotine Reduction

FRIDAY, Sept. 7, 2018 (HealthDay News) -- Immediate reduction of nicotine in cigarettes leads to significantly greater decreases in biomarkers of smoke exposure than gradual reductions in nicotine levels, according to a study published in the Sept. 4 issue of the Journal of the American Medical Association.

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Metabolite Analysis IDs Pathways Associated With WTC-Lung Injury

FRIDAY, Sept. 7, 2018 (HealthDay News) -- Machine learning approaches to metabolite analysis can predict key pathways contributing to lung function loss associated with World Trade Center Lung Injury (WTC-LI), according to a small study published online Sept. 3 in BMJ Open Respiratory Research.

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Increased Corticomotor Excitability ID'd in Restless Legs

FRIDAY, Sept. 7, 2018 (HealthDay News) -- For patients with restless leg syndrome (RLS), the primary motor cortex (M1) exhibits hyperexcitability, which is associated with disease severity, according to a study published recently in Sleep Medicine.

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Greater CAD Incidence, Heart Mass in Firefighter Cardiac Arrests

FRIDAY, Sept. 7, 2018 (HealthDay News) -- Most cardiac fatalities among firefighters have evidence of coronary heart disease and increased heart mass, according to a study published online Sept. 5 in the Journal of the American Heart Association.

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Personalized Weighting Could Enhance Hospital Rating Tools

FRIDAY, Sept. 7, 2018 (HealthDay News) -- The weighting systems that underlie hospital performance rating tools should incorporate the needs, values, and preferences of patients, according to a perspective article published in the Aug. 30 issue of the New England Journal of Medicine.

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Better Training Needed to Boost LGBTQ Patient Health Care

THURSDAY, Sept. 6, 2018 (HealthDay News) -- High-quality health care needs to be provided to lesbian, gay, bisexual, transgender, and queer (LGBTQ) patients, and improved training is necessary to deliver that care, according to a report published in the American Medical Association's AMA Wire.

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Hospital Groups Launch Own Generic Drug Company

THURSDAY, Sept. 6, 2018 (HealthDay News) -- Three U.S. health care foundations and seven hospital groups have formed a generic drug company to combat high prices and chronic shortages of medicines.

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Widespread Statin Use Not Recommended in Old, Very Old

THURSDAY, Sept. 6, 2018 (HealthDay News) -- Statin use is not associated with reduced risk of atherosclerotic cardiovascular disease (CVD) or all-cause mortality among older adults without type 2 diabetes, according to a study published online Sept. 5 in The BMJ.

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Chronic Vaping Exerts Biological Effects on Lung

THURSDAY, Sept. 6, 2018 (HealthDay News) -- Chronic vaping exerts biological effects on the lung, some of which are mediated by the propylene glycol/vegetable glycerin (PG/VG) base, according to a study published recently in the American Journal of Respiratory and Critical Care Medicine.

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Public Service Loan Forgiveness Program Has Uncertain Future

WEDNESDAY, Sept. 5, 2018 (HealthDay News) -- Uncertainty surrounds the future of the Public Service Loan Forgiveness (PSLF) program, according to an Ideas and Opinions article published online Aug. 28 in the Annals of Internal Medicine.

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Fostamatinib Seems Effective for Immune Thrombocytopenia

WEDNESDAY, Sept. 5, 2018 (HealthDay News) -- Fostamatinib produces clinically meaningful responses in adults with immune thrombocytopenia (ITP), according a study published in the July issue of the American Journal of Hematology.

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~3,000 Excess Deaths Estimated Due to Hurricane Maria

WEDNESDAY, Sept. 5, 2018 (HealthDay News) -- The total excess mortality attributed to Hurricane Maria is estimated at 2,975 deaths, according to a report issued by George Washington University.

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Immune Cells' Gene Expression May Predict Flu Susceptibility

WEDNESDAY, Sept. 5, 2018 (HealthDay News) -- KLRD1-expressing natural killer cells may be a biomarker for influenza susceptibility, according to a study published recently in Genome Medicine.

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Enrollment in High-Deductible Health Plans Up From '07 to '17

TUESDAY, Sept. 4, 2018 (HealthDay News) -- Enrollment in high-deductible health plans (HDHPs) has increased among adults with employment-based insurance coverage, according to an August data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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