March 2019 Briefing - Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for March 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Perception of E-Cigarettes as More Harmful Than Cigarettes Increased

FRIDAY, March 29, 2019 (HealthDay News) -- From 2012 to 2017, the proportion of U.S. adults who perceived electronic-cigarettes to be as harmful as or more harmful than cigarettes increased, according to a study published online March 29 in JAMA Network Open.

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Questions Remain About Safety of Parkinson Disease Psychosis Drug

FRIDAY, March 29, 2019 (HealthDay News) -- There are many unanswered questions about the safety and effectiveness of a drug used to combat hallucinations and delusions in Parkinson disease patients, says a report from a drug safety group. The nonprofit Institute for Safe Medication Practices (ISMP) called for Nuplazid to have stronger warnings on its label for patients and their families, CNN reported.

CNN Article

Long-Term Phentermine Use Safe, Effective for Weight Loss

FRIDAY, March 29, 2019 (HealthDay News) -- Patients taking phentermine for weight loss for more than three months experience greater weight loss without an increased risk for incident cardiovascular disease or death, according to a study published online March 21 in Obesity.

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Use of Biologics to Treat IBD in U.S. Adults May Be Suboptimal

FRIDAY, March 29, 2019 (HealthDay News) -- Varied study design and methodology make it difficult to assess real-world trends in adherence and persistence in use of biologics among U.S. adults with inflammatory bowel disease (IBD), according to a review published online March 14 in the Journal of Clinical Pharmacy and Therapeutics.

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Lifetime HTN Risk High for Black Men and Women, White Men

THURSDAY, March 28, 2019 (HealthDay News) -- Lifetime risks of hypertension under the American Heart Association (AHA) and American College of Cardiology (ACC) 2017 threshold exceed 75 percent for white men and African-American men and women, according to a study published online March 27 in JAMA Cardiology.

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Cimzia Injection Approved for New Inflammatory Arthritis Indication

THURSDAY, March 28, 2019 (HealthDay News) -- Cimzia (certolizumab pegol) injection has been approved to treat adults with nonradiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation, the U.S. Food and Drug Administration announced.

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Guidance Lists New First-Line Treatment for Severe Malaria in the U.S.

THURSDAY, March 28, 2019 (HealthDay News) -- The drug artesunate -- the World Health Organization-recommended first-line treatment for severe malaria -- will become the first-line treatment for severe malaria in the United States, the U.S. Centers for Disease Control and Prevention says in a new guidance to health care providers.

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Docetaxel Chemo Ups Survival in High-Risk Localized Prostate Cancer

THURSDAY, March 28, 2019 (HealthDay News) -- Adding docetaxel-based chemotherapy (CT) to standard treatment for high-risk nonmetastatic prostate cancer improves survival, according to a study published online March 12 in the Journal of Clinical Oncology.

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Drug Survival Rates Highest for Ustekinumab for Pediatric Psoriasis

THURSDAY, March 28, 2019 (HealthDay News) -- In real-life conditions, drug survival rates are higher for ustekinumab than for adalimumab and etanercept for all treatments and types of psoriasis in children, according to a study published online March 18 in the Journal of the European Academy of Dermatology and Venereology.

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FDA Grants Approval for Hypogonadism Treatment

THURSDAY, March 28, 2019 (HealthDay News) -- Jatenzo (testosterone undecanoate), an oral testosterone capsule, has been approved to treat men with certain forms of hypogonadism, the U.S. Food and Drug Administration announced Wednesday.

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Receiving Activated Charcoal Bag Tied to Proper Opioid Disposal

THURSDAY, March 28, 2019 (HealthDay News) -- Providing patients undergoing surgical procedures with an activated charcoal bag for opioid deactivation could increase appropriate opioid disposal, according to a research letter published online March 27 in JAMA Surgery.

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Contact Lens-Based Antihistamine Delivery Effective

THURSDAY, March 28, 2019 (HealthDay News) -- A contact lens (CL)-based drug delivery system is effective for therapeutic delivery of the antihistamine ketotifen, according to a study published online March 19 in Cornea.

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Tx Adherence for Inflammatory Bowel Dz Lower in the Educated

WEDNESDAY, March 27, 2019 (HealthDay News) -- Nonadherence to inflammatory bowel disease (IBD) treatment is more common among wealthier, more educated patients, according to a study published online March 18 in JGH Open.

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User Data From Medicine-Related Apps Routinely Shared

WEDNESDAY, March 27, 2019 (HealthDay News) -- User data from medicine-related apps are routinely shared, according to a study published online March 20 in The BMJ.

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Taxane + Platinum Feasible for Adjuvant Tx in Endometrial Cancer

WEDNESDAY, March 27, 2019 (HealthDay News) -- Taxane plus platinum regimens may be a reasonable alternative to doxorubicin plus cisplatin as postoperative adjuvant chemotherapy for endometrial cancer that carries a high risk for progression, according to a study published online March 21 in JAMA Oncology.

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FDA Approves Mayzent for Relapsing Multiple Sclerosis

WEDNESDAY, March 27, 2019 (HealthDay News) -- Mayzent (siponimod) pills have been approved by the U.S. Food and Drug Administration for adults with relapsing multiple sclerosis.

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Douglas County, Colorado, Ranked as Healthiest Community

TUESDAY, March 26, 2019 (HealthDay News) -- The 2019 healthiest community in America is Douglas County, Colorado, according to a report published online March 26 by U.S. News & World Report, in conjunction with the Aetna Foundation.

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$775 Million Settlement Reached in Xarelto Lawsuits

TUESDAY, March 26, 2019 (HealthDay News) -- A settlement of $775 million will be paid to settle lawsuits involving the blood thinner Xarelto, Johnson & Johnson and Bayer said Monday.

The New York Times Article

Statins Cut Risk for Major Vascular Events in Older Patients

TUESDAY, March 26, 2019 (HealthDay News) -- Statins reduce the rate of vascular events regardless of patient age, according to a meta-analysis recently published in The Lancet.

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Topical Immunotx for Actinic Keratosis May Prevent Cancer

MONDAY, March 25, 2019 (HealthDay News) -- A short course of calcipotriol plus 5-fluorouracil (5-FU) treatment for actinic keratosis (AK) is associated with induction of robust T cell immunity and reduced development of squamous cell carcinoma (SCC) within three years, according to a study published in the March 21 issue of JCI Insight.

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Analysis IDs Messages Behind Antivaccination Comments

FRIDAY, March 22, 2019 (HealthDay News) -- Arguments against vaccination remain consistent within subgroups of individuals, according to a study published online March 18 in Vaccine.

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FDA: Higher Risk for Death Found With Venclexta in Multiple Myeloma

FRIDAY, March 22, 2019 (HealthDay News) -- A safety statement was issued yesterday by the U.S. Food and Drug Administration regarding risks found to be associated with the investigational use of Venclexta (venetoclax) for treatment of patients with multiple myeloma.

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Many Patients Still Employ Strategies to Reduce Prescription Drug Costs

FRIDAY, March 22, 2019 (HealthDay News) -- The number of adults reporting the use of strategies, such as requesting a lower-cost medication or not using medication as prescribed, to reduce prescription drug costs remained stable in 2015 to 2017, according to a March data brief published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.

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Recent Increase Reported in Drug Overdose Deaths Involving Fentanyl

THURSDAY, March 21, 2019 (HealthDay News) -- From 2011 to 2016, there was an increase in drug overdose deaths involving fentanyl, according to the March 21 National Vital Statistics Reports, a publication from the U.S. Centers for Disease Control and Prevention.

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DG/health NATURALS Cough Syrup + Mucus for Infants Recalled

THURSDAY, March 21, 2019 (HealthDay News) -- One lot of DG/health NATURALS baby Cough Syrup + Mucus is being recalled due to possible contamination with potentially harmful bacteria, says maker Kingston Pharma, LLC.

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Cannabidiol Products Now Available at Hundreds of CVS Stores

THURSDAY, March 21, 2019 (HealthDay News) -- Creams, sprays, and lotions infused with the nonintoxicating hemp component cannabidiol (CBD) are now being sold at more than 800 CVS stores in eight states.

Chicago Tribune Article
More Information: CDC

In Youth With ADHD, New-Onset Psychosis Up With Amphetamines

THURSDAY, March 21, 2019 (HealthDay News) -- For adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD), new-onset psychosis occurs more often with amphetamine use versus methylphenidate use, according to a study published in the March 21 issue of the New England Journal of Medicine.

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Antibiotics, PPIs Tied to Higher C. Diff Risk in Hospitalized Children

THURSDAY, March 21, 2019 (HealthDay News) -- Previous antibiotic exposure and use of proton pump inhibitors (PPIs) may be risk factors for Clostridioides (formerly Clostridium) difficile infection (CDI) in hospitalized pediatric patients, according to a review published online March 7 in Infection Control & Hospital Epidemiology.

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Statins Tied to Insulin Resistance, Higher Serum Fasting Insulin

THURSDAY, March 21, 2019 (HealthDay News) -- Individuals using statins may be at higher risk for hyperglycemia, insulin resistance, and eventually type 2 diabetes, according to a study published online March 5 in the British Journal of Clinical Pharmacology.

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Three Factors Predict Psych Events With Drugs for Smoking Cessation

THURSDAY, March 21, 2019 (HealthDay News) -- Three factors predict clinically significant neuropsychiatric adverse events (NPSAEs) in smokers with or without mental health conditions who use cessation pharmacotherapy, according to a study published online March 7 in the Journal of General Internal Medicine.

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Trastuzumab Tied to Higher Long-Term Risk for Heart Failure

WEDNESDAY, March 20, 2019 (HealthDay News) -- Compared with chemotherapy alone, trastuzumab is associated with a twofold increased long-term risk for heart failure in breast cancer survivors, according to a study published in the March 1 issue of JACC: Heart Failure.

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FDA: First Treatment Approved Specifically for Postpartum Depression

WEDNESDAY, March 20, 2019 (HealthDay News) -- Zulresso (brexanolone) injection has been approved for intravenous (IV) use in the treatment of postpartum depression (PPD) in adult women, marking the first drug approved specifically for PPD, the U.S. Food and Drug Administration announced yesterday.

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FDA OKs Tecentriq for Extensive-Stage Small Cell Lung Cancer

TUESDAY, March 19, 2019 (HealthDay News) -- Tecentriq (atezolizumab) has been approved by the U.S. Food and Drug Administration to treat adults with extensive-stage small cell lung cancer.

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Bluetooth Technology Enables Insulin Adherence Monitoring

TUESDAY, March 19, 2019 (HealthDay News) -- Adherence to timing and dosing of insulin injections can be objectively measured using Bluetooth-enabled pen caps, according to a study published online March 12 in Diabetes Care.

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Active Interventions Generally Helpful for Urinary Incontinence

MONDAY, March 18, 2019 (HealthDay News) -- Most active interventions are more likely than no treatment to improve outcomes for women with either stress or urgency urinary incontinence (UI), according to a review published online March 19 in the Annals of Internal Medicine.

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Average of 8.8 Inactive Ingredients Found in Oral Medications

MONDAY, March 18, 2019 (HealthDay News) -- Oral forms of medications contain an average of 8.8 inactive ingredients, many of which could cause adverse reactions, according to a perspective piece published in the March 13 issue of Science Translational Medicine.

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Young Child Goes to ED for Medicine Poisoning Every 10 Minutes

FRIDAY, March 15, 2019 (HealthDay News) -- The number of children younger than age 6 years treated at U.S. emergency departments for medicine poisonings has declined in recent years, but there were still nearly 52,000 cases in 2017, a new report says.

CNN Article
Safe Kids Worldwide Report

EPA Proposal Will Allow Antibiotic Spraying of Citrus Crops

FRIDAY, March 15, 2019 (HealthDay News) -- The U.S. Environmental Protection Agency proposal to allow use of the antibiotic streptomycin to treat citrus disease should be withdrawn because it poses a risk to human health and the environment, Consumer Reports says.

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Testosterone Therapy in Hypogonadism Can Prevent Progression to T2DM

FRIDAY, March 15, 2019 (HealthDay News) -- Testosterone therapy (TTh) can prevent progression to type 2 diabetes (T2D) in men with prediabetes and hypogonadism, according to a study published online March 12 in Diabetes Care.

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Guidelines Developed for Polymyxin Antibiotic Use

FRIDAY, March 15, 2019 (HealthDay News) -- Recommendations have been developed for use of polymyxins, focusing on polymyxin B and polymyxin E (colistin); the guidelines were recently published in Pharmacotherapy.

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Opioid Prescriptions Dropped for New Users From 2012 to 2017

FRIDAY, March 15, 2019 (HealthDay News) -- Many providers stopped initiating opioid therapy from July 2012 to December 2017, according to a report published in the March 14 issue of the New England Journal of Medicine.

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AAP: Nasal Spray Vaccine Against Flu Acceptable in 2019 to 2020

THURSDAY, March 14, 2019 (HealthDay News) -- The American Academy of Pediatrics (AAP) plans to advise families to vaccinate children against influenza with either the flu shot or nasal spray vaccine during the 2019 to 2020 flu season, in contrast to the academy's preference for the injected vaccine over the nasal spray during the previous two flu seasons, the AAP announced today.

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Prenatal High-Dose Vitamin D Not Linked to Asthma at Age 6

THURSDAY, March 14, 2019 (HealthDay News) -- High-dose vitamin D supplementation in pregnancy is not associated with a child's risk for asthma at age 6 years, according to a research letter published in the March 12 issue of the Journal of the American Medical Association.

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One-Month Regimen Noninferior for Preventing HIV-Related TB

THURSDAY, March 14, 2019 (HealthDay News) -- For HIV-infected patients, a one-month regimen of rifapentine and isoniazid is noninferior to nine months of isoniazid alone for preventing tuberculosis, according to a study published in the March 14 issue of the New England Journal of Medicine.

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Complex Dosing, Polypharmacy Common With Interstitial Lung Disease

THURSDAY, March 14, 2019 (HealthDay News) -- Polypharmacy and complex medication regimens are common in patients with interstitial lung disease (ILD), according to a study published online Feb. 20 in Respirology.

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Short Regimen Noninferior for Rifampin-Resistant Tuberculosis

WEDNESDAY, March 13, 2019 (HealthDay News) -- A short regimen is noninferior to a long regimen for patients with rifampin-resistant tuberculosis that is susceptible to fluoroquinolones and aminoglycosides, according to a study published online March 13 in the New England Journal of Medicine.

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FDA Approves New Generic Valsartan to Ease Shortage

WEDNESDAY, March 13, 2019 (HealthDay News) -- The U.S. Food and Drug Administration on Tuesday approved a new generic version of the high blood pressure/heart failure drug valsartan, saying the move might help ease the current medication shortage.

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Head of National Cancer Institute Named Acting FDA Commissioner

WEDNESDAY, March 13, 2019 (HealthDay News) -- The U.S. Food and Drug Administration will temporarily be overseen by the head of the National Cancer Institute when FDA Commissioner Scott Gottlieb, M.D., leaves the post next month.

AP News Article

Adding Bempedoic Acid to Statin Therapy Reduces LDL Cholesterol

WEDNESDAY, March 13, 2019 (HealthDay News) -- Bempedoic acid, an inhibitor of ATP citrate lyase (ACLY), added to maximally tolerated statin therapy, significantly reduces levels of low-density lipoprotein (LDL) cholesterol in patients with atherosclerotic cardiovascular disease and/or heterozygous familial hypercholesterolemia, according to a study published in the March 14 issue of the New England Journal of Medicine.

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CDC: Most Americans Report Excellent, Good Health

WEDNESDAY, March 13, 2019 (HealthDay News) -- Most Americans report having excellent or good health and have a usual place to go for medical care, according to a report published March 13 for the National Health Interview Survey Early Release Program.

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Elderly Men Undertreated for Osteoporosis

WEDNESDAY, March 13, 2019 (HealthDay News) -- Elderly men are significantly undertreated for osteoporosis, according to a study published online March 5 in the Journal of Pharmaceutical Health Services Research.

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Tramadol May Up Mortality Risk in Osteoarthritis Patients

TUESDAY, March 12, 2019 (HealthDay News) -- The initial prescription of tramadol compared with commonly prescribed nonsteroidal anti-inflammatory drugs may be associated with increased all-cause mortality among patients with osteoarthritis, according to a study published in the March 12 issue of the Journal of the American Medical Association.

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Four-to-Seven-Day Opioid Rx Likely Sufficient for Acute Pain Treatment

TUESDAY, March 12, 2019 (HealthDay News) -- An opioid supply for seven or fewer days might be sufficient for most patients seen in primary care settings for acute pain who appear to need opioid analgesics, according to research published in the Feb. 15 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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CDC: Flu Season May Have Peaked

MONDAY, March 11, 2019 (HealthDay News) -- It looks like the flu season has peaked in the United States, though there has been a recent rise in the number of cases involving a more severe flu strain.

AP News Article
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Dual Receipt of Opioids Tied to Increased Risk for OD Death

MONDAY, March 11, 2019 (HealthDay News) -- For veterans enrolled in the U.S. Department of Veterans Affairs (VA) and Medicare Part D, receipt of opioids from both VA and Part D is associated with an increased likelihood of death from prescription opioid overdose, according to a study published online March 12 in the Annals of Internal Medicine.

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FDA Approves First Immunotherapy Drug for Breast Cancer

MONDAY, March 11, 2019 (HealthDay News) -- The U.S. Food and Drug Administration has given its blessing to the first immunotherapy regimen for breast cancer.

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Children With Poorly Controlled Asthma Suffer Academically

MONDAY, March 11, 2019 (HealthDay News) -- Urban children with asthma, particularly those who are ethnic minorities, have more school absences than their peers without asthma, according to a study published online March 11 in the Annals of Allergy, Asthma, & Immunology.

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Timing of Medicare Loss Linked to Kidney Transplant Outcomes

MONDAY, March 11, 2019 (HealthDay News) -- Kidney transplant recipients receiving Medicare who lose coverage before or after the current three-year policy time point have an increased risk for allograft loss, according to a study published online March 5 in the American Journal of Transplantation.

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Only About Half of Elderly Newly Diagnosed With ALL Receive Tx

FRIDAY, March 8, 2019 (HealthDay News) -- Almost half of elderly patients newly diagnosed with acute lymphoblastic leukemia (ALL) do not receive treatment, according to a study recently published in Leukemia & Lymphoma.

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Tenapanor Reduces Elevated Serum Phosphate in CKD

FRIDAY, March 8, 2019 (HealthDay News) -- For hyperphosphatemic patients with chronic kidney disease receiving maintenance hemodialysis, tenapanor significantly reduces elevated serum phosphate, according to a study published online March 7 in the Journal of the American Society of Nephrology.

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Dasotraline Promising for the Treatment of ADHD in Children

FRIDAY, March 8, 2019 (HealthDay News) -- Treatment with dasotraline (4 mg/day) significantly improves attention-deficit/hyperactivity disorder (ADHD) symptoms in children aged 6 to 12 years, according to a study published online March 7 in the Journal of Child and Adolescent Psychopharmacology.

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Persistent, Prolonged Opioid Use Occurs After Plastic Surgery

THURSDAY, March 7, 2019 (HealthDay News) -- Persistent and prolonged opioid use occur after plastic and reconstructive surgical procedures, according to a study published online March 7 in JAMA Facial Plastic Surgery.

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Long-Term Systemic Hormone Therapy May Up Alzheimer Risk

THURSDAY, March 7, 2019 (HealthDay News) -- Long-term use of systemic hormone therapy may be associated with an increased risk for Alzheimer disease, according to a study published online March 6 in The BMJ.

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Fluorouracil Cream Best Choice for Tx of Actinic Keratosis Lesions

WEDNESDAY, March 6, 2019 (HealthDay News) -- For patients with multiple actinic keratosis lesions on the head, 5 percent fluorouracil cream is the most effective treatment, according to a study published in the March 7 issue of the New England Journal of Medicine.

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About 360,000 ED Visits Were for Nonmedical Drug Abuse in 2016

WEDNESDAY, March 6, 2019 (HealthDay News) -- In 2016, there were an estimated 358,247 emergency department visits for harms from nonmedical use of pharmaceuticals, according to a study published online March 6 in the American Journal of Preventive Medicine.

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FDA Approves Ketamine-Like Drug for Severe Depression

WEDNESDAY, March 6, 2019 (HealthDay News) -- The U.S. Food and Drug Administration on Tuesday approved the nasal spray medication esketamine -- a relative of the club drug and anesthetic ketamine -- for use against severe depression. Sold as Spravato, the fast-acting drug becomes the first new type of medicine approved in years against an illness that affects millions of Americans.

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AAP: Social Media Companies Must Curb Spread of Vaccine Myths

TUESDAY, March 5, 2019 (HealthDay News) -- Google, Facebook, and Pinterest need to take more action against the growing threat to children posed by online misinformation about vaccines, the American Academy of Pediatrics said in a letter sent to the social media companies.

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FDA Commissioner Dr. Scott Gottlieb Resigns

TUESDAY, March 5, 2019 (HealthDay News) -- In what probably came as a surprise to many, U.S. Food and Drug Administration Commissioner Scott Gottlieb, M.D., announced his resignation on Tuesday. Gottlieb is leaving the FDA because he wants to spend more time with his wife and three young daughters -- twins aged 9 and a 5-year-old -- one official said. He currently commutes each week from the family home in Connecticut to his Washington, D.C., office.

The Washington Post Article

Studies Look at Ways to Reduce Depressive Episodes in Obese

TUESDAY, March 5, 2019 (HealthDay News) -- For overweight adults with depression, daily multinutrient supplements and individual or group therapy sessions do not reduce major depressive disorder (MDD) episodes over one year, but an integrated intervention appears to be beneficial, according to two studies published in the March 5 issue of the Journal of the American Medical Association.

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Program in Peds Rheumatology Clinic Ups Education on Teratogenic Rx

TUESDAY, March 5, 2019 (HealthDay News) -- A series of interventions introduced through a quality improvement project can increase the frequency of both teratogen education and urine pregnancy screening in patients taking teratogenic medications for rheumatic disease, according to a study published online March 5 in Pediatrics.

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Recommendations Developed for Ulcerative Colitis Management

TUESDAY, March 5, 2019 (HealthDay News) -- Recommendations have been developed for management of adults with ulcerative colitis (UC); the American College of Gastroenterology clinical guideline was published online Feb. 21 in the American Journal of Gastroenterology.

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Low-Dose Aspirin Does Not Cut Death From Prostate Cancer

MONDAY, March 4, 2019 (HealthDay News) -- Low-dose aspirin use does not appear to reduce the overall risk for prostate cancer death, according to a study published online March 5 in the Annals of Internal Medicine.

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MMR Not Linked to Autism in Danish Cohort Study

MONDAY, March 4, 2019 (HealthDay News) -- Measles, mumps, rubella (MMR) vaccination is not associated with an increased risk for autism, including in children with autism risk factors, according to a study published online March 5 in the Annals of Internal Medicine.

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Eli Lilly to Sell Cheaper Version of Insulin Drug

MONDAY, March 4, 2019 (HealthDay News) -- A cheaper version of Eli Lilly's most popular insulin drug, Humalog, is being introduced by the drug maker.

The New York Times Article

Pneumococcal Vaccination at Age 50 Prevents the Most Disease

MONDAY, March 4, 2019 (HealthDay News) -- Recommending pneumococcal vaccination for all 50-year-olds prevents the most disease in underserved minorities and the general population, but the cost exceeds $250,000 per quality-adjusted life-year (QALY) gained, according to a study published online March 4 in Vaccine.

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Multidimensional Approach Cuts Unneeded Drug-Drug Interaction Alerts

MONDAY, March 4, 2019 (HealthDay News) -- An iterative, multidimensional quality improvement (QI) effort can reduce interruptive drug-drug interaction (DDI) alerts, according to a study published in the March issue of Pediatrics.

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FDA Warns Americans Not to Buy Drugs From Canadian Company

FRIDAY, March 1, 2019 (HealthDay News) -- A large Canadian drug distributor sells unapproved and mislabeled medicines to Americans, the U.S. Food and Drug Administration warned Thursday. The distributor disputes the claim, however.

The New York Times Article
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Antibiotic Delay Leads to Increased Risks in Seniors With UTI

FRIDAY, March 1, 2019 (HealthDay News) -- Delaying or withholding antibiotics for older patients with a urinary tract infection (UTI) is associated with an increase in bloodstream infection and all-cause mortality, according to a study published online Feb. 27 in The BMJ.

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Drivers' Opioid Use Associated With Fatal Car Crashes

FRIDAY, March 1, 2019 (HealthDay News) -- Drivers' use of prescription opioids is associated with initiation of fatal two-vehicle crashes independent of alcohol use, according to a study published online Feb. 15 in JAMA Network Open.

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Long-Term Cardiomyopathy Risk Varies by Chemo Agent

FRIDAY, March 1, 2019 (HealthDay News) -- Long-term cardiomyopathy risk varies by chemotherapy agent for childhood cancer survivors, with a decreased risk for daunorubicin versus doxorubicin, according to a study recently published in JAMA Oncology.

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